Publications of F. Ulrich Hartl

Kamps, J.; Yuste-Checa, P.; Mamashli, F.; Schmitz, M.; Herrera, M. G.; da Silva Correia, S. M.; Gogte, K.; Bader, V.; Zerr, I.; Hartl, F. U. et al.; Bracher, A.; Winklhofer, K. F.; Tatzelt, J.: Regulated Proteolysis Induces Aberrant Phase Transition of Biomolecular Condensates into Aggregates: A Protective Role for the Chaperone Clusterin. Journal of Molecular Biology 436 (23), 168839 (2024)

Wales, T. E.; Pajak, A.; Roeselova, A.; Shivakumaraswamy, S.; Howell, S.; Kjaer, S.; Hartl, F. U.; Engen, J. R.; Balchin, D.: Resolving chaperone-assisted protein folding on the ribosome at the peptide level. Nature Structural & Molecular Biology 31 (12), pp. 1888 - 1897 (2024)

Wagner, J.; Carvajal Alvarez, A. I.; Bracher, A.; Beck, F.; Wan, W.; Bohn, S.; Körner, R.; Baumeister, W.; Fernandez-Busnadiego, R.; Hartl, F. U.: Visualizing chaperonin function in situ by cryo-electron tomography. Nature 633 (8029), pp. 459 - 464 (2024)

Krainer, G.; Jacquat, R. P. B.; Schneider, M. M.; Welsh, T. J.; Fan, J.; Peter, Q. A. E.; Andrzejewska, E. A.; Sneideriene, G.; Czekalska, M. A.; Ausserwoeger, H. et al.; Chai, L.; Arter, W. E.; Saar, K. L.; Herling, T. W.; Franzmann, T. M.; Kosmoliaptsis, V.; Alberti, S.; Hartl, F. U.; Lee, S. F.; Knowles, T. P. J.: Single-molecule digital sizing of proteins in solution. Nature Communications 15 (1), 7740 (2024)

Cairo, L. V.; Hong, X.; Mueller, M. B. D.; Yuste-Checa, P.; Jagadeesan, C.; Bracher, A.; Park, S.-H.; Hayer-Hartl, M.; Hartl, F. U.: Stress-dependent condensate formation regulated by the ubiquitin-related modifier Urm1. Cell 187 (17), pp. 4656 - 4673.e28 (2024)

Shimanovich, U.; Hartl, F. U.: Protein folding: From physico-chemical rules and cellular machineries of protein quality control to AI solutions. Proceedings of the National Academy of Sciences of the United States of America 121 (34), e2411135121 (2024)

Hipp, M. S.; Hartl, F. U.: Interplay of proteostasis capacity and Pprotein aggregation: Implications for cellular function and disease. Journal of Molecular Biology 436 (14), 168615 (2024)

Zhao, D. Y.; Bäuerlein, F. J. B.; Saha, I.; Hartl, F. U.; Baumeister, W.; Wilfling, F.: Autophagy preferentially degrades non-fibrillar polyQ aggregates. Molecular Cell 84 (10), pp. 1980 - 1994 (2024)

Furthmann, N.; Bader, V.; Angersbach, L.; Blusch, A.; Goel, S.; Sanchez-Vicente, A.; Krause, L. J.; Chaban, S. A.; Grover, P.; Trinkaus, V. A. et al.; van Well, E. M.; Jaugstetter, M.; Tschulik, K.; Damgaard, R. B.; Saft, C.; Ellrichmann, G.; Gold, R.; Koch, A.; Englert, B.; Westenberger, A.; Klein, C.; Jungbluth, L.; Sachse, C.; Behrends, C.; Glatzel, M.; Hartl, F. U.; Nakamura, K.; Christine, C. W.; Huang, E. J.; Tatzelt, J.; Winklhofer, K. F.: NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62. Nature Communications 14 (1), 8368 (2023)

Müller, M. B. D.; Kasturi, P.; Jayaraj, G. G.; Hartl, F. U.: Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control. Cell 186 (15), pp. 3227 - 3244 (2023)

Saha, I.; Yuste-Checa, P.; Padilha, M. D. S.; Guo, Q.; Körner, R.; Holthusen, H.; Trinkaus, V. A.; Dudanova, I.; Fernandez-Busnadiego, R.; Baumeister, W. et al.; Sanders, D. W.; Gautam, S.; Diamond, M. I.; Hartl, F. U.; Hipp, M. S.: The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system. Nature Communications 14 (1), 560 (2023)

Eisele-Bürger, A. M.; Eisele, F.; Malmgren Hill, S.; Hao, X.; Schneider, K. L.; Imamoglu, R.; Balchin, D.; Liu, B.; Hartl, F. U.; Bozhkov, P. V. et al.; Nyström, T.: Calmodulin regulates protease versus co-chaperone activity of a metacaspase. Cell Reports 42, 113372 (2023)

Gropp, M. H. M.; Klaips, C. L.; Hartl, F. U.: Formation of toxic oligomers of polyQ-expanded Huntingtin by prion-mediated cross-seeding. Molecular Cell 82 (22), pp. 4290 - 4306 (2022)

Yuste-Checa, P.; Bracher, A.; Hartl, F. U.: The chaperone Clusterin in neurodegeneration-friend or foe? Bioessays 44 (7), e2100287 (2022)

Riemenschneider, H.; Guo, Q.; Bader, J. M.; Frottin, F.; Farny, D.; Kleinberger, G.; Haass, C.; Mann, M.; Hartl, F. U.; Baumeister, W. et al.; Hipp, M. S.; Meissner, F.; Fernandez-Busnadiego, R.; Edbauer, D.: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. EMBO Reports 23 (6), e53890 (2022)

Blumenstock, S.; Schulz-Trieglaff, K.; Voelkl, K.; Bolender, A.-L.; Lapios, P.; Lindner, J.; Hipp, M. S.; Hartl, F. U.; Klein, R.; Dudanova, I.: Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease. EMBO Journal 40 (19), e107260 (2021)

Frottin, F.; Perez-Berlanga, M.; Hartl, F. U.; Hipp, M. S.: Multiple pathways of toxicity induced by c9orf72 dipeptide repeat aggregates and G(4)C(2) RNA in a cellular model. eLife 10, e62718 (2021)

Schneider, M. M.; Gautam, S.; Herling, T. W.; Andrzejewska, E.; Krainer, G.; Miller, A. M.; Trinkaus, V. A.; Peter, Q. A. E.; Ruggeri, F. S.; Vendruscolo, M. et al.; Bracher, A.; Dobson, C. M.; Hartl, F. U.; Knowles, T. P. J.: The Hsc70 disaggregation machinery removes monomer units directly from alpha-synuclein fibril ends. Nature Communications 12 (1), 5999 (2021)

Sitron, C. S.; Hartl, F. U.: A new way of D/Ealing with protein misfolding. Molecular Cell 81 (20), pp. 4114 - 4115 (2021)

Trinkaus, V. A.; Riera-Tur, I.; Martinez Sanchez, A.; Bäuerlein, F. J. B.; Guo, Q.; Arzberger, T.; Baumeister, W.; Dudanova, I.; Hipp, M. S.; Hartl, F. U. et al.; Fernandez-Busnadiego, R.: In situ architecture of neuronal alpha-Synuclein inclusions. Nature Communications 12 (1), 2110 (2021)