Publications of Reinhard Fässler

Guo, S. S.; Liu, Z.; Wang, G. M.; Sun, Z.; Yu, K.; Fawcett, J. P.; Buettner, R.; Gao, B.; Fässler, R.: KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation. Nature Communications 15 (1), 10381 (2024)

Yu, K.; Wang, G. M.; Guo, S. S.; Bassermann, F.; Fässler, R.: The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation. EMBO Reports 2024 (25), pp. 5687 - 5718 (2024)

Link, K.; Muhandes, L.; Polikarpova, A.; Lammermann, T.; Sixt, M.; Fassler, R.; Roers, A.: Integrin b1-mediated mast cell immune-surveillance of blood vessel content. The journal of Allergy and Clinical Immunology 154 (3), pp. 745 - 753 (2024)

Wang, W.; Atherton, P.; Kreft, M.; te Molder, L.; van der Poel, S.; Hoekman, L.; Celie, P.; Joosten, R. P.; Fässler, R.; Perrakis, A. et al.; Sonnenberg, A.: Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility. Methods in Cell Science 137 (9), jcs262116 (2024)

Watanabe-Takano, H.; Kato, K.; Oguri-Nakamura, E.; Ishii, T.; Kobayashi, K.; Murata, T.; Tsujikawa, K.; Miyata, T.; Kubota, Y.; Hanada, Y. et al.; Nishiyama, K.; Watabe, T.; Fässler, R.; Ishii, H.; Mochizuki, N.; Fukuhara, S.: Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts. Nature Communications 15, 1622 (2024)

Hsu, C.-P.; Aretz, J.; Hordeichyk, A.; Fässler, R.; Bausch, A. R.: Surface-induced phase separation of reconstituted nascent integrin clusters on lipid membranes. Proceedings of the National Academy of Sciences of the United States of America 120 (31), e2301881120 (2023)

Bodescu, M. A.; Aretz, J.; Grison, M.; Rief, M.; Fässler, R.: Kindlin stabilizes the talin integrin bond under mechanical load by generating an ideal bond. Proceedings of the National Academy of Sciences of the United States of America 120 (26), e2218116120 (2023)

Huber, M.; Casares-Arias, J.; Fässler, R.; Mueller, D. J.; Strohmeyer, N.: In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells. Nature Communications 14 (1), 2143 (2023)

Aretz, J.; Aziz, M.; Strohmeyer, N.; Sattler, M.; Fässler, R.: Talin and kindlin use integrin tail allostery and direct binding to activate integrins. Nature Structural & Molecular Biology 30, pp. 1913 - 1924 (2023)

Guo, S. S.; Fässler, R.: KANK proteins. Current Biology 32 (19), pp. R990 - R992 (2022)

Sevilla-Movilla, S.; Fuentes, P.; Rodriguez-Garcia, Y.; Arellano-Sanchez, N.; Krenn, P. W.; Isern de Val, S.; Montero-Herradon, S.; Garcia-Ceca, J.; Burdiel-Herencia, V.; Gardeta, S. R. et al.; Aguilera-Montilla, N.; Barrio-Alonso, C.; Crainiciuc, G.; Bouvard, D.; Garcia-Pardo, A.; Zapata, A. G.; Hidalgo, A.; Fässler, R.; Carrasco, Y. R.; Toribio, M. L.; Teixido, J.: ICAP-1 loss impairs CD8(+) thymocyte development and leads to reduced marginal zone B cells in mice. European Journal of Immunology 52 (8), pp. 1228 - 1242 (2022)

Thievessen, I.; Suhr, F.; Vergarajauregui, S.; Böttcher, R. T.; Brixius, K.; Rosenberger, G.; Dewald, O.; Fleischmann, B. K.; Ghanem, A.; Kruger, M. et al.; Engel, F. B.; Fabry, B.; Bloch, W.; Fässler, R.: The focal adhesion protein beta-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load. Current Biology 32 (14), pp. 3033 - 3047 (2022)

de Faria, J. P.; Vale-Silva, R. S.; Fässler, R.; Werner, H. B.; Relvas, J. B.: Pinch2 regulates myelination in the mouse central nervous system. Development 149 (13), dev200597 (2022)

Zuidema, A.; Atherton, P.; Kreft, M.; Hoekman, L.; Bleijerveld, O. B.; Nagaraj, N.; Chen, N.; Fässler, R.; Sonnenberg, A.: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins. Journal of Cell Biology 221 (8), e202108027 (2022)

Zuidema, A.; Wang, W.; Kreft, M.; Bleijerveld, O. B.; Hoekman, L.; Aretz, J.; Böttcher, R. T.; Fässler, R.; Sonnenberg, A.: Molecular determinants of alpha V beta 5 localization in flat clathrin lattices - role of alpha V beta 5 in cell adhesion and proliferation. Journal of Cell Science 135 (11), jcs259465 (2022)

Chen, N.-P.; Aretz, J.; Fässler, R.: CDK1-cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry. Nature Cell Biology 24, pp. 723 - 736 (2022)

Böttcher, R. T.; Strohmeyer, N.; Aretz, J.; Fässler, R.: New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain. Life science alliance 5 (4), e202101301 (2022)

Fischer, A.; Wannemacher, J.; Christ, S.; Koopmans, T.; Kadri, S.; Zhao, J. K.; Gouda, M.; Ye, H. F.; Muck-Hausl, M.; Krenn, P. W. et al.; Machens, H. G.; Fässler, R.; Neumann, P. A.; Hauck, S. M.; Rinkevich, Y.: Neutrophils direct preexisting matrix to initiate repair in damaged tissues. Nature Immunology 23 (4), pp. 518 - 531 (2022)

Shi, Y.; Berking, A.; Baade, T.; Legate, K. R.; Fässler, R.; Hauck, C. R.: PIP5KI gamma 90-generated phosphatidylinositol-4,5-bisphosphate promotes the uptake of Staphylococcus aureus by host cells. Molecular Microbiology 116, pp. 1249 - 1267 (2021)

Bulus, N.; Brown, K. L.; Mernaugh, G.; Böttcher, A.; Dong, X.; Sanders, C. R.; Pozzi, A.; Fässler, R.; Zent, R.: Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice. The Journal of Biological Chemistry 296, 100361 (2021)