Publications of Ozge Karayel

Gottemukkala, K. V.; Chrustowicz, J.; Sherpa, D.; Sepic, S.; Tung Vu, D.; Karayel, O.; Papadopoulou, E. C.; Gross, A.; Schorpp, K.; von Gronau, S. et al.; Hadian, K.; Murray, P. J.; Mann, M.; Schulman, B. A.; Alpi, A. F.: Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. Molecular Cell 84 (10), pp. 1948 - 1963.e11 (2024)

Chrustowicz, J.; Sherpa, D.; Li, J.; Langlois, C. R.; Papadopoulou, E. C.; Tung Vu, D.; Hehl, L. A.; Karayel, Ö.; Beier, V.; Gronau, S. v. et al.; Müller, J.; Prabu, J. R.; Mann, M.; Kleiger, G.; Alpi, A. F.; Schulman, B. A.: Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Molecular Cell 84 (2), pp. 293 - 308 (2024)

Hansen, F. M.; Kremer, L. S.; Karayel, O.; Bludau, I.; Larsson, N.-G.; Kühl, I.; Mann, M.: Mitochondrial phosphoproteomes are functionally specialized across tissues. Life Science Alliance 7, e202302147 (2024)

Schmidt, S.; Stautner, C.; Tung Vu, D.; Heinz, A.; Regensburger, M.; Karayel, O.; Truembach, D.; Artati, A.; Kaltenhaeuser, S.; Nassef, M. Z. et al.; Hembach, S.; Steinert, L.; Winner, B.; Juergen, W.; Jastroch, M.; Luecken, M. D.; Theis, F. J.; Westmeyer, G. G.; Adamski, J.; Mann, M.; Hiller, K.; Giesert, F.; Weisenhorn, D. M. V.; Wurst, W.: A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease. Nature Communications 14 (1), 7674 (2023)

Schweizer, L.; Schaller, T.; Zwiebel, M.; Karayel, O.; Müller-Reif, J. B.; Zeng, W.-F.; Dintner, S.; Nordmann, T. M.; Hirschbuehl, K.; Maerkl, B. et al.; Claus, R.; Mann, M.: Quantitative multiorgan proteomics of fatal COVID-19 uncovers tissue-specific effects beyond inflammation. EMBO Molecular Medicine 15 (9), e17459 (2023)

Sherpa, D.; Mueller, J.; Karayel, Ö.; Xu, P.; Yao, Y.; Chrustowicz, J.; Gottemukkala, K. V.; Baumann, C. A.; Gross, A.; Czarnecki, O. et al.; Zhang, W.; Gu, J.; Nilvebrant, J.; Sidhu, S. S.; Murray, P. J.; Mann, M.; Weiss, M. J.; Schulman, B. A.; Alpi, A. F.: Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation. eLife 11, e77937 (2022)

Skowronek, P.; Thielert, M.; Voytik, E.; Tanzer, M. C.; Hansen, F. M.; Willems, S.; Karayel, O.; Brunner, A.-D.; Meier, F.; Mann, M.: Rapid and in-depth coverage of the (phospho-) proteome with deep libraries and optimal window design for dia-PASEF. Molecular & Cellular Proteomics 21 (9), 100279 (2022)

Sirinian, C.; Papanastasiou, A. D.; Karayel, O.; Degn, S. E.; Peroukidis, S.; Chaniotis, D.; Nonni, A.; Repanti, M.; Kriegsmann, M.; Makatsoris, T. et al.; Koutras, A.; Mann, M.; Kalofonos, H. P.: Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness. Neoplasia 33, 100836 (2022)

Mehta, S.; Buyanbat, A.; Kai, Y.; Karayel, O.; Goldman, S. R.; Seruggia, D.; Zhang, K.; Fujiwara, Y.; Donovan, K. A.; Zhu, Q. et al.; Yang, H.; Nabet, B.; Gray, N. S.; Mann, M.; Fischer, E. S.; Adelman, K.; Orkin, S. H.: Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degra-dation of BCL11A protein in erythroid cells. Cell Chemical Biology 29 (8), pp. 1273 - 1287 (2022)

Steger, M.; Karayel, Ö.; Demichev, V.: Ubiquitinomics: History, methods, and applications in basic research and drug discovery. Proteomics 22 (15-16), e2200074 (2022)

Karayel, O.; Winter, S.; Padmanabhan, S.; Kuras I, Y.; Tung Vu, D.; Tuncali, I.; Merchant, K.; Wills, A.-M.; Scherzer, C. R.; Mann, M.: Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson's disease. Cell Reports Medicine 3 (6), 100661 (2022)

Langlois, C. R.; Beier, V.; Karayel, O.; Chrustowicz, J.; Sherpa, D.; Mann, M.; Schulman, B. A.: A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters. EMBO Reports 23 (6), e53835 (2022)

Qiao, S.; Lee, C.-W.; Sherpa, D.; Chrustowicz, J.; Cheng, J. D.; Duennebacke, M.; Steigenberger, B.; Karayel, O.; Tung Vu, D.; Gronau, S. v. et al.; Mann, M.; Wilfling, F.; Schulman, B.: Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Nature Communications 13 (1), 3041 (2022)

Bludau, I.; Willems, S.; Zeng, W.-F.; Strauss, M. T.; Hansen, F. M.; Tanzer, M. C.; Karayel, O.; Schulman, B. A.; Mann, M.: The structural context of posttranslational modifications at a proteome-wide scale. PLoS Biology 20 (5), e3001636 (2022)

Kutzner, K.; Woods, S.; Karayel, O.; Gehring, T.; Yin, H.; Flatley, A.; Grass, C.; Wimberger, N.; Tofaute, M. J.; Seeholzer, T. et al.; Feederle, R.; Mann, M.; Krappmann, D.: Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells. Science Signaling 15 (723), eabk3083 (2022)

Yin, H.; Karayel, O.; Chao, Y.-Y.; Seeholzer, T.; Hamp, I.; Plettenburg, O.; Gehring, T.; Zielinski, C.; Mann, M.; Krappmann, D.: A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-kappa B signaling in activated T cells. Cellular and Molecular Life Sciences 79 (2), 112 (2022)

Liwocha, J.; Krist, D. T.; van der Heden van Noort, G.J.; Hansen, F. M.; Truong, V.H.; Karayel, O.; Purser, N.; Houston, D.; Burton, N.; Bostock, M.J. et al.; Sattler, M.; Mann, M.; Harrison, J.S.; Kleiger, G.; Ovaa, H.; Schulman, B. A.: Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature Chemical Biology 17, pp. 272 - 279 (2021)

Hansen, F. M.; Tanzer, M. C.; Brüning, F.; Bludau, I.; Stafford, C.; Schulman, B. A.; Robles, M. S.; Karayel, O.; Mann, M.: Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology. Nature Communications 12 (1), 254 (2021)

Sherpa, D.; Chrustowicz, J.; Qiao, S.; Langlois, C. R.; Hehl, L. A.; Gottemukkala, K. V.; Hansen, F. M.; Karayel, O.; von Gronau, S.; Prabu, J. R. et al.; Mann, M.; Alpi, A. F.; Schulman, B. A.: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Molecular Cell 81 (11), pp. 2445 - 2459.e13 (2021)

Stukalov, A.; Girault, V.; Grass, V.; Karayel, O.; Bergant, V.; Urban, C.; Haas, D. A.; Huang, Y.; Oubraham, L.; Wang, A. et al.; Hamad, M. S.; Piras, A.; Hansen, F. M.; Tanzer, M. C.; Paron, I.; Zinzula, L.; Engleitner, T.; Reinecke, M.; Lavacca, T. M.; Ehmann, R.; Woelfel, R.; Jores, J.; Kuster, B.; Protzer, U.; Rad, R.; Ziebuhr, J.; Thiel, V.; Scaturro, P.; Mann, M.; Pichlmair, A.: Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 594 (7862), pp. 246 - 252 (2021)