Publications of Fynn M. Hansen

El Fissi, N.; Rosenberger, F. A.; Chang, K.; Wilhalm, A.; Barton-Owen, T.; Hansen, F. M.; Golder, Z.; Alsina, D.; Wedell, A.; Mann, M. et al.; Chinnery, P. F.; Freyer, C.; Wredenberg, A.: Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster. Nature Communications 15 (1), 10719 (2024)

Jiang, S.; Yuan, T.; Rosenberger, F. A.; Mourier, A.; Dragano, N. R. V.; Kremer, L. S.; Rubalcava-Gracia, D.; Hansen, F. M.; Borg, M.; Mennuni, M. et al.; Filograna, R.; Alsina, D.; Misic, J.; Koolmeister, C.; Papadea, P.; de Angelis, M. H.; Ren, L.; Andersson, O.; Unger, A.; Bergbrede, T.; Di Lucrezia, R.; Wibom, R.; Zierath, J. R.; Krook, A.; Giavalisco, P.; Mann, M.; Larsson, N.-G.: Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nature Metabolism 6 (6), pp. 1024 - 1035 (2024)

Li, J.; Purser, N.; Liwocha, J.; Scott, D. C.; Byers, H. A.; Steigenberger, B.; Hill, S.; Tripathi-Giesgen, I.; Hinkle, T.; Hansen, F. M. et al.; Prabu, J. R.; Radhakrishnan, S. K.; Kirkpatrick, D. S.; Reichermeier, K. M.; Schulman, B. A.; Kleiger, G.: Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Molecular Cell 84 (7), pp. 1304 - 1320 (2024)

Hansen, F. M.; Kremer, L. S.; Karayel, O.; Bludau, I.; Larsson, N.-G.; Kühl, I.; Mann, M.: Mitochondrial phosphoproteomes are functionally specialized across tissues. Life Science Alliance 7, e202302147 (2024)

Tubío-Santamaría, N.; Jayavelu, A. K.; Schnoeder, T. M.; Eifert, T.; Hsu, C.-J.; Perner, F.; Zhang, Q.; Wenge, D. V.; Hansen, F. M.; Kirkpatrick, J. M. et al.; Jyotsana, N.; Lane, S. W.; von Eyss, B.; Deshpande, A. J.; Kühn, M. W. M.; Schwaller, J.; Cammann, C.; Seifert, U.; Ebstein, F.; Krüger, E.; Hochhaus, A.; Heuser, M.; Ori, A.; Mann, M.; Armstrong, S. A.; Heidel, F. H.: Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia. Molecular Cancer 22, 196 (2023)

Zecha, J.; Bayer, F. P.; Wiechmann, S.; Woortman, J.; Berner, N.; Mueller, J.; Schneider, A.; Kramer, K.; Abril-Gil, M.; Hopf, T. et al.; Reichart, L.; Chen, L.; Hansen, F. M.; Lechner, S.; Samaras, P.; Eckert, S.; Lautenbacher, L.; Reinecke, M.; Hamood, F.; Prokofeva, P.; Vornholz, L.; Falcomata, C.; Dorsch, M.; Schroeder, A.; Venhuizen, A.; Wilhelm, S.; Medard, G.; Stoehr, G.; Ruland, J.; Gruener, B. M.; Saur, D.; Buchner, M.; Ruprecht, B.; Hahne, H.; The, M.; Wilhelm, M.; Kuster, B.: Decrypting drug actions and protein modifications by dose- and time-resolved proteomics. Science 380 (6640), pp. 93 - 101 (2023)

Skowronek, P.; Thielert, M.; Voytik, E.; Tanzer, M. C.; Hansen, F. M.; Willems, S.; Karayel, O.; Brunner, A.-D.; Meier, F.; Mann, M.: Rapid and in-depth coverage of the (phospho-) proteome with deep libraries and optimal window design for dia-PASEF. Molecular & Cellular Proteomics 21 (9), 100279 (2022)

Bludau, I.; Willems, S.; Zeng, W.-F.; Strauss, M. T.; Hansen, F. M.; Tanzer, M. C.; Karayel, O.; Schulman, B. A.; Mann, M.: The structural context of posttranslational modifications at a proteome-wide scale. PLoS Biology 20 (5), e3001636 (2022)

Voytik, E.; Bludau, I.; Willems, S.; Hansen, F. M.; Brunner, A.-D.; Strauss, M. T.; Mann, M.: AlphaMap: An open-source Python package for the visual annotation of proteomics data with sequence-specific knowledge. Bioinformatics 38 (3), pp. 849 - 852 (2022)

Liwocha, J.; Krist, D. T.; van der Heden van Noort, G.J.; Hansen, F. M.; Truong, V.H.; Karayel, O.; Purser, N.; Houston, D.; Burton, N.; Bostock, M.J. et al.; Sattler, M.; Mann, M.; Harrison, J.S.; Kleiger, G.; Ovaa, H.; Schulman, B. A.: Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature Chemical Biology 17, pp. 272 - 279 (2021)

Frauenstein, A.; Ebner, S.; Hansen, F. M.; Sinha, A.; Phulphagar, K.; Swatek, K.; Hornburg, D.; Mann, M.; Meissner, F.: Identification of covalent modifications regulating immune signaling complex composition and phenotype. Molecular Systems Biology 17 (7), e10125 (2021)

Hansen, F. M.; Tanzer, M. C.; Brüning, F.; Bludau, I.; Stafford, C.; Schulman, B. A.; Robles, M. S.; Karayel, O.; Mann, M.: Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology. Nature Communications 12 (1), 254 (2021)

Müller-Reif, J. B.; Hansen, F. M.; Schweizer, L.; Treit, P. V.; Geyer, P. E.; Mann, M.: A New Parallel High-Pressure Packing System Enables Rapid Multiplexed Production of Capillary Columns. Molecular and Cellular Proteomics 20, 100082 (2021)

Sherpa, D.; Chrustowicz, J.; Qiao, S.; Langlois, C. R.; Hehl, L. A.; Gottemukkala, K. V.; Hansen, F. M.; Karayel, O.; von Gronau, S.; Prabu, J. R. et al.; Mann, M.; Alpi, A. F.; Schulman, B. A.: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Molecular Cell 81 (11), pp. 2445 - 2459.e13 (2021)

Stukalov, A.; Girault, V.; Grass, V.; Karayel, O.; Bergant, V.; Urban, C.; Haas, D. A.; Huang, Y.; Oubraham, L.; Wang, A. et al.; Hamad, M. S.; Piras, A.; Hansen, F. M.; Tanzer, M. C.; Paron, I.; Zinzula, L.; Engleitner, T.; Reinecke, M.; Lavacca, T. M.; Ehmann, R.; Woelfel, R.; Jores, J.; Kuster, B.; Protzer, U.; Rad, R.; Ziebuhr, J.; Thiel, V.; Scaturro, P.; Mann, M.; Pichlmair, A.: Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 594 (7862), pp. 246 - 252 (2021)

Heim, V. J.; Dagley, L. F.; Stafford, C. A.; Hansen, F. M.; Clayer, E.; Bankovacki, A.; Webb, A. I.; Lucet, I. S.; Silke, J.; Nachbur, U.: A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity. EMBO Reports 21 (11), e50400 (2020)

Qiao, S.; Langlois, C. R.; Chrustowicz, J.; Sherpa, D.; Karayel, O.; Hansen, F. M.; Beier, V.; von Gronau, S.; Bollschweiler, D.; Schäfer, T. et al.; Alpi, A. F.; Mann, M.; Prabu, J. R.; Schulman, B.: Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. MOLECULAR CELL 77 (1), pp. 150 - 163.e9 (2020)

Hansen, F.: Improvement of mass spectrometry-based analysis of posttranslational modification with a special focus on protein ubiquitination. Dissertation, Ludwig-Maximilians-Universität München, Fakultät für Chemie und Pharmazie, München (2022)