Publications of R. Huber

Borelli, C.; Ruge, E.; Schaller, M.; Monod, M.; Korting, H. C.; Huber, R.; Maskos, K.: The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A. Proteins-Structure Function and Bioinformatics 68 (3), pp. 738 - 748 (2007)

Steiner, T.; Lamerz, A.C.; Hess, P.; Breithaupt, C.; Krapp, S.; Bourenkov, G.; Huber, R.; Gerardy-Schahn, R.; Jacob, U.: Open and Closed Structures of the UDP-glucose Pyrophosphorylase from Leishmania major. Journal of Biological Chemistry 282 (17), pp. 13003 - 13010 (2007)

Huber, R.: Biochemical nanomachines. Tissue Engineering 13 (4), p. 867 - 867 (2007)

Kyrieleis, O. J. P.; Huber, R.; Ong, E.; Oehler, R.; Hunter, M.; Madison, E. L.; Jacob, U.: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family. FEBS Journal 274 (8), pp. 2148 - 2160 (2007)

Keil, C.; Maskos, K.; Than, M.; Hoopes, J.T.; Huber, R.; Tan, F.; Deddish, P.A.; Erdös, E.G.; Skidgel, R.A.; Bode, W.: Crystal Structure of the Human Carboxypeptidase N (Kininase I) Catalytic Domain. Journal of Molecular Biology 366, pp. 504 - 516 (2007)

Debela, M.; Magdolen, V.; Grimminger, V.; Sommerhoff, C.; Messerschmidt, A.; Huber, R.; Friedrich, R.; Bode, W.; Goettig, P.: Crystal structures of human tissue kallikrein 4: Activity modulation by a specific zinc binding site. Journal of Molecular Biology 362 (5), pp. 1094 - 1107 (2006)

Breithaupt, C.; Kurzbauer, R.; Lilie, H.; Schaller, A.; Strassner, J.; Huber, R.; Macheroux, P.; Clausen, T.: Crystal structure of 12-oxophytodienoate reductase 3 from tomato: Self-inhibition by dimerization. Proceedings of the National Academy of Sciences of the United States of America 103 (39), pp. 14337 - 14342 (2006)

Tamulaitiene, G.; Jakubauskas, A.; Urbanke, C.; Huber, R.; Grazulis, S.; Siksnys, V.: The crystal structure of the rare-cutting restriction enzyme Sdal reveals unexpected domain architecture. Structure 14 (9), pp. 1389 - 1400 (2006)

Chatwell, L.; Krojer, T.; Fidler, A.; Romisch, W.; Eisenreich, W.; Bacher, A.; Huber, R.; Fischer, M.: Biosynthesis of riboflavin: Structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5 '-phosphate reductase of Methanocaldococcus jannaschii. Journal of Molecular Biology 359 (5), pp. 1334 - 1351 (2006)

Groll, M.; Huber, R.; Potts, B. C. M.: Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding. Journal of the American Chemical Society 128 (15), pp. 5136 - 5141 (2006)

Groll, M.; Larionov, O. V.; Huber, R.; de Meijere, A.: Inhibitor-binding mode of homobelactosin C to proteasomes: New insights into class I MHC ligand generation. Proceedings of the National Academy of Sciences of the United States of America 103 (12), pp. 4576 - 4579 (2006)

Rohr, K. B.; Selwood, T.; Marquardt, U.; Huber, R.; Schechter, N. M.; Bode, W.; Than, M. E.: X-ray structures of free and leupeptin-complexed human alpha I-tryptase mutants: Indication for an alpha ->beta-tryptase transition. Journal of Molecular Biology 357 (1), pp. 195 - 209 (2006)

Engel, M.; Hoffmann, T.; Manhart, S.; Heiser, U.; Chambre, S.; Huber, R.; Demuth, H. U.; Bode, W.: Rigidity and flexibility of dipeptidyl peptidase IV: Crystal structures of and docking experiments with DPIV. Journal of Molecular Biology 355 (4), pp. 768 - 783 (2006)

Ramsperger, A.; Augustin, M.; Schott, A. K.; Gerhardt, S.; Krojer, T.; Eisenreich, W.; Illarionov, B.; Cushman, M.; Bacher, A.; Huber, R. et al.; Fischer, M.: Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor - Stereochemical implications. Journal of Biological Chemistry 281 (2), pp. 1224 - 1232 (2006)

Huber, R.: Molecular machines for protein degradation. Free Radical Research 40 (Suppl. Suppl. 1), p. S35 - S35 (2006)

Schaefer, B.; Pellkofer, H.; Breithaupt, C.; Huber, R.; Jacob, U.: Targeting Fcgamma receptors in the treatment of multiple sclerosis. Clinical Immunology 119 (Suppl. Suppl. S), pp. S115 - S116 (2006)

Sitar, T.; Popowicz, G. M.; Siwanowicz, I.; Huber, R.; Holak, T.: Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proceedings of the National Academie of Sciences 103, pp. 13028 - 13033 (2006)

Golbik, R.; Yu, C.; Weyher-Stingl, E.; Huber, R.; Moroder, L.; Budisa, N.; Schiene-Fischer, C.: Peptidyl prolyl cis/trans-isomerases: Comparative reactivities of cyclophilins, FK506-binding proteins, and parvulins with fluorinated oligopeptide and protein substrates. Biochemistry 44 (49), pp. 16026 - 16034 (2005)

Grazulis, S.; Manakova, E.; Roessle, M.; Bochtler, M.; Tamulaitiene, G.; Huber, R.; Siksnys, V.: Structure of the metal-independent restriction enzyme Bfil reveals fusion of a specific DNA-binding domain with a nonspecific nuclease. Proceedings of the National Academy of Sciences of the United States of America 102 (44), pp. 15797 - 15802 (2005)

Breitenlechner, C. B.; Kairies, N. A.; Honold, K.; Scheiblich, S.; Koll, H.; Greiter, E.; Koch, S.; Schafer, W.; Huber, R.; Engh, R. A.: Crystal structures of active Src kinase domain complexes. Journal of Molecular Biology 353 (2), pp. 222 - 231 (2005)