Publications of R. A. Engh

Prime, M. E.; Courtney, S. M.; Brookfield, F. A.; Marston, R. W.; Walker, V.; Warne, J.; Boyd, A. E.; Kairies, N. A.; von der Saal, W.; Limberg, A. et al.; Georges, G.; Engh, R. A.; Goller, B.; Rueger, P.; Rueth, M.: Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase. Journal of Medicinal Chemistry 54 (1), pp. 312 - 319 (2011)

Bonn, S.; Herrero, S.; Breitenlechner, C. B.; Erlbruch, A.; Lehmann, W.; Engh, R. A.; Gassel, M.; Bossemeyer, D.: Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity. Journal of Biological Chemistry 281 (34), pp. 24818 - 24830 (2006)

Breitenlechner, C. B.; Kairies, N. A.; Honold, K.; Scheiblich, S.; Koll, H.; Greiter, E.; Koch, S.; Schafer, W.; Huber, R.; Engh, R. A.: Crystal structures of active Src kinase domain complexes. Journal of Molecular Biology 353 (2), pp. 222 - 231 (2005)

Wisniewska, M.; Bossenmaier, B.; Georges, G.; Hesse, F.; Dangl, M.; Kunkele, K. P.; Ioannidis, I.; Huber, R.; Engh, R. A.: The 1.1 angstrom resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. Journal of Molecular Biology 347 (5), pp. 1005 - 1014 (2005)

Breitenlechner, C. B.; Friebe, W. G.; Brunet, E.; Guido, W.; Graul, M.; Thomas, U.; Kunkele, K. P.; Schafer, W.; Gassel, M.; Bosseineyer, D. et al.; Huber, R.; Engh, R. A.; Masjost, B.: Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase a and mutants. Journal of Medicinal Chemistry 48 (1), pp. 163 - 170 (2005)

Siwanowicz, I.; Popowicz, G. M.; Wisniewska, M.; Huber, R.; Kuenkele, K. P.; Lang, K.; Engh, R. A.; Holak, T. A.: Structural basis for the regulation of insulin-like growth factors by IGF binding proteins. Structure 13 (1), pp. 155 - 167 (2005)

Breitenlechner, C.; Engh, R. A.; Huber, R.; Kinzel, V.; Bossemeyer, D.; Gassel, M.: The typically disordered n-terminus of PKA can fold as a helix and project the myristoylation site into solution. Biochemistry 43 (24), pp. 7743 - 7749 (2004)

Gassel, M.; Breitenlechner, C. B.; Konig, N.; Huber, R.; Engh, R. A.; Bossemeyer, D.: The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A. Journal of Biological Chemistry 279 (22), pp. 23679 - 23690 (2004)

Breitenlechner, C. B.; Wegge, T.; Berillon, L.; Graul, K.; Marzenell, M.; Friebe, W. G.; Thomas, U.; Schumacher, R.; Huber, R.; Engh, R. A. et al.; Masjost, B.: Structure-based optimization of novel azepane derivatives as PKB inhibitors. Journal of Medicinal Chemistry 47 (6), pp. 1375 - 1390 (2004)

Breitenlechner, C.; Gassel, M.; Engh, R.; Bossemeyer, D.: Structural insights into AGC kinase inhibition. Oncology Research 14 (6), pp. 267 - 278 (2004)

Klein, C.; Hesse, F.; Dehner, A.; Engh, R. A.; Schwaiger, M.; Hansen, S.: In vitro folding and characterization of the p53 DNA binding domain. Biological Chemistry 385 (1), pp. 95 - 102 (2004)

Breitenlechner, C.; Gassel, M.; Hidaka, H.; Kinzel, V.; Huber, R.; Engh, R. A.; Bossemeyer, D.: Protein kinase a in complex with rho-kinase inhibitors Y-27632, fasudil, and H-1152P: Structural basis of selectivity. Structure 11 (12), pp. 1595 - 1607 (2003)

Bossemeyer, D.; Gassel, M.; Breitenlechner, C. B.; de Vega, S. H.; Engh, R. A.: Insights into AGC-kinase inhibitor binding from studies with PKA. Abstracts of Papers of the American Chemical Society 226, p. U461 - U461 (2003)

Gassel, M.; Breitenlechner, C. B.; Ruger, P.; Jucknischke, U.; Schneider, T.; Huber, R.; Bossemeyer, D.; Engh, R. A.: Mutants of protein kinase a that mimic the ATP-binding site of protein kinase B (AKT). Journal of Molecular Biology 329 (5), pp. 1021 - 1034 (2003)

Gassel, M.; Breitenlechner, C. B.; De Vega, S. H.; Engh, R. A.; Bossemeyer, D.: Structural insights into AGC-kinase inhibitor binding from studies with the workhorse PKA. Cellular & Molecular Biology Letters 8 (2A), pp. 508 - 509 (2003)

Gaßel, M.; Breitenlechner, C. B.; Engh, R. A.; Bossemeyer, D.: Crystal structure of an altered catalytic subunit of cAMP-dependent protein kinase in complex with the Pkc-kinase inhibitor Bisindolyl-Maleimide 2 in two different conformations - implications for selectivity. Cellular and Molecular Biology Letters 8, p. 582 - 582 (2003)

Kamionka, M.; Rehm, T.; Beisel, H. G.; Lang, K.; Engh, R. A.; Holak, T. A.: In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction. Journal of Medicinal Chemistry 45 (26), pp. 5655 - 5660 (2002)

Seifert, M. H. J.; Breitenlechner, C. B.; Bossemeyer, D.; Huber, R.; Holak, T. A.; Engh, R. A.: Phosphorylation and flexibility of cyclic-AMP-dependent protein kinase (PKA) using P-31 NMR Spectroscopy. Biochemistry 41 (19), pp. 5968 - 5977 (2002)

Engh, R. A.; Bossemeyer, D.: Structural aspects of protein kinase control - role of conformational flexibility. Pharmacology & Therapeutics 93 (2-3), pp. 99 - 111 (2002)