Publications of M. Groll

Gallastegui, N.; Beck, P.; Arciniega, M.; Huber, R.; Hillebrand, S.; Groll, M.: Hydroxyureas as Noncovalent Proteasome Inhibitors. Angewandte Chemie-International Edition 51 (1), pp. 247 - 249 (2012)

Gräwert, M. A.; Gallastegui, N.; Stein, M.; Schmidt, B.; Kloetzel, P. M.; Huber, R.; Groll, M.: Elucidation of the alpha-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition. Angewandte Chemie-International Edition 50 (2), pp. 542 - 544 (2011)

Groll, M.; Gallastegui, N.; Marechal, X.; Le Ravalec, V.; Basse, N.; Richy, N.; Genin, E.; Huber, R.; Moroder, L.; Vidal, J. et al.; Reboud-Ravaux, M.: 20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A. ChemMedChem 5 (10), pp. 1701 - 1705 (2010)

Clerc, J.; Schellenberg, B.; Groll, M.; Bachmann, A. S.; Huber, R.; Dudler, R.; Kaiser, M.: Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors. European Journal of Organic Chemistry (21), pp. 3991 - 4003 (2010)

Groll, M.; Gallastegui, N.; Maréchal, X.; Le Ravalec, V.; Basse, N.; Richy, N.; Genin, E.; Huber, R.; Moroder, L.; Vidal, J. et al.; Reboud-Ravaux, M.: 20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A. ChemMedChem 5, pp. 1701 - 1705 (2010)

Clerc, J.; Florea, B. I.; Kraus, M.; Groll, M.; Huber, R.; Bachmann, A. S.; Dudler, R.; Driessen, C.; Overkleeft, H. S.; Kaiser, M.: Syringolin A Selectively Labels the 20 S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines. ChemBioChem 10 (16), pp. 2638 - 2643 (2009)

Clerc, J.; Groll, M.; Illich, D. J.; Bachmann, A. S.; Huber, R.; Schellenberg, B.; Dudler, R.; Kaiser, M.: Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition. Proceedings of the National Academy of Sciences of the United States of America 106 (16), pp. 6507 - 6512 (2009)

Groll, M.; Huber, R.; Moroder, L.: The persisting challenge of selective and specific proteasome inhibition. Journal of Peptide Science 15 (2), pp. 58 - 66 (2009)

Groll, M.; Schellenberg, B.; Bachmann, A. S.; Archer, C. R.; Huber, R.; Powell, T. K.; Lindow, S.; Kaiser, M.; Dudler, R.: A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism. NATURE 452 (7188), pp. 755 - 758 (2008)

Gotz, M. G.; Groll, M.; Kaiser, M.; Weyher, E.; Moroder, L.: MEDI 24-Macrocyclic peptidyl biaryl-ether inhibitors provide evidence for the catalytic versatility of the 20S proteasome. Abstracts of Papers of the American Chemical Society 235, p. 24-MEDI (2008)

Groll, M.; Götz, M.; Kaiser, M.; Weyher, E.; Moroder, L.: TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome. Chemistry & Biology 13 (6), pp. 607 - 614 (2006)

Groll, M.; Huber, R.; Potts, B. C. M.: Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding. Journal of the American Chemical Society 128 (15), pp. 5136 - 5141 (2006)

Groll, M.; Larionov, O. V.; Huber, R.; de Meijere, A.: Inhibitor-binding mode of homobelactosin C to proteasomes: New insights into class I MHC ligand generation. Proceedings of the National Academy of Sciences of the United States of America 103 (12), pp. 4576 - 4579 (2006)

Goettig, P.; Brandstetter, H.; Groll, M.; Göhring, W.; Konarev, P. V.; Svergun, D. I.; Huber, R.; Kim, J. S.: X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum. Journal of Biological Chemistry 280 (39), pp. 33387 - 33396 (2005)

Groll, M.; Bochtler, M.; Brandstetter, H.; Clausen, T.; Huber, R.: Molecular machines for protein degradation. ChemBioChem 6 (2), pp. 222 - 256 (2005)

Groll, M.; Huber, R.: Purification, crystallization, and x-ray analysis of the yeast 20S proteasome. Methods in Enzymology 398, pp. 329 - 336 (2005)

Groll, M.; Huber, R.: Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach. Biochimica et Biophysica Acta-Molecular Cell Research 1695 (1-3), pp. 33 - 44 (2004)

Kaiser, M.; Groll, M.; Siciliano, C.; Assfalg-Machleidt, I.; Weyher, E.; Kohno, J.; Milbradt, A. G.; Renner, C.; Huber, R.; Moroder, L.: Binding mode of TMC-95A analogues to eukaryotic 20S proteasome. ChemBioChem 5 (9), pp. 1256 - 1266 (2004)

Kaiser, M.; Milbradt, A. G.; Siciliano, C.; Assfalg-Machleidt, I.; Machleidt, W.; Groll, M.; Renner, C.; Moroder, L.: TMC-95A analogues with endocyclic biphenyl ether group as proteasome inhibitors. Chemistry & Biodiversity 1 (1), pp. 161 - 173 (2004)

Kaiser, M.; Siciliano, C.; Assfalg-Machleidt, I.; Groll, M.; Milbradt, A. G.; Moroder, L.: Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling. Organic Letters 5 (19), pp. 3435 - 3437 (2003)