Publications of T. Clausen

Tennstaedt, A.; Popsel, S.; Truebestein, L.; Hauske, P.; Brockmann, A.; Schmidt, N.; Irle, I.; Sacca, B.; Niemeyer, C. M.; Brandt, R. et al.; Ksiezak-Reding, H.; Tirniceriu, A. L.; Egensperger, R.; Baldi, A.; Dehmelt, L.; Kaiser, M.; Huber, R.; Clausen, T.; Ehrmann, M.: Human High Temperature Requirement Serine Protease A1 (HTRA1) Degrades Tau Protein Aggregates. Journal of Biological Chemistry 287 (25), pp. 20931 - 20941 (2012)

Clausen, T.; Kaiser, M.; Huber, R.; Ehrmann, M.: HTRA proteases: regulated proteolysis in protein quality control. Nature Reviews Molecular Cell Biology 12 (3), pp. 152 - 162 (2011)

Merdanovic, M.; Clausen, T.; Kaiser, M.; Huber, R.; Ehrmann, M.: Protein Quality Control in the Bacterial Periplasm. Annual Review of Microbiology 65, pp. 149 - 168 (2011)

Krojer, T.; Sawa, J.; Huber, R.; Clausen, T.: HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues. Nature Structural & Molecular Biology 17 (7), pp. 844 - 852 (2010)

Hasenbein, S.; Meltzer, M.; Hauske, P.; Kaiser, M.; Huber, R.; Clausen, T.; Ehrmann, M.: Conversion of a Regulatory into a Degradative Protease. Journal of Molecular Biology 397 (4), pp. 957 - 966 (2010)

Meltzer, M.; Hasenbein, S.; Mamant, N.; Merdanovic, M.; Poepsel, S.; Hauske, P.; Kaiser, M.; Huber, R.; Krojer, T.; Clausen, T. et al.; Ehrmann, M.: Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli. Research in Microbiology 160 (9 Sp. Iss.), pp. 660 - 666 (2009)

Breithaupt, C.; Kurzbauer, R.; Schaller, F.; Stintzi, A.; Schaller, A.; Huber, R.; Macheroux, P.; Clausen, T.: Structural Basis of Substrate Specificity of Plant 12-Oxophytodienoate Reductases. Journal of Molecular Biology 392 (5), pp. 1266 - 1277 (2009)

Krojer, T.; Pangerl, K.; Kurt, J.; Sawa, J.; Stingl, C.; Mechtler, K.; Huber, R.; Ehrmann, M.; Clausen, T.: Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proceedings of the National Academy of Sciences of the United States of America 105 (22), pp. 7702 - 7707 (2008)

Breithaupt, C.; Kurzbauer, R.; Lilie, H.; Schaller, A.; Strassner, J.; Huber, R.; Macheroux, P.; Clausen, T.: Crystal structure of 12-oxophytodienoate reductase 3 from tomato: Self-inhibition by dimerization. Proceedings of the National Academy of Sciences of the United States of America 103 (39), pp. 14337 - 14342 (2006)

Groll, M.; Bochtler, M.; Brandstetter, H.; Clausen, T.; Huber, R.: Molecular machines for protein degradation. ChemBioChem 6 (2), pp. 222 - 256 (2005)

Messerschmidt, A.; Worbs, M.; Steegborn, C.; Wahl, M. C.; Huber, R.; Laber, B.; Clausen, T.: Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzyme family: Crystal structure of cystathionine γ-lyase from yeast and intrafamiliar structure comparison. Biological Chemistry 384 (3), pp. 373 - 386 (2003)

Kaiser, J. T.; Bruno, S.; Clausen, T.; Huber, R.; Schiaretti, F.; Mozzarelli, A.; Kessler, D.: Snapshots of the cystine lyase C-DES during catalysis - Studies in solution and in the crystalline state. Journal of Biological Chemistry 278 (1), pp. 357 - 365 (2003)

Clausen, T.; Southan, C.; Ehrmann, M.: The HtrA family of proteases: Implications for protein composition and cell fate. Molecular Cell 10 (3), pp. 443 - 455 (2002)

Garrido-Franco, M.; Laber, B.; Huber, R.; Clausen, T.: Enzyme-ligand complexes of pyridoxine 5 -phosphate synthase: Implications for substrate binding and catalysis. Journal of Molecular Biology 321 (4), pp. 601 - 612 (2002)

Bertoldi, M.; Cellini, B.; Clausen, T.; Voltattorni, C. B.: Spectroscopic and kinetic analyses reveal the pyridoxal 5 '- phosphate binding mode and the catalytic features of Treponema denticola cystalysin. Biochemistry 41 (29), pp. 9153 - 9164 (2002)

Garrido-Franco, M.; Ehlert, S.; Messerschmidt, A.; Marinkovic, S.; Huber, R.; Laber, B.; Bourenkov, G. P.; Clausen, T.: Structure and function of threonine synthase from yeast. Journal of Biological Chemistry 277 (14), pp. 12396 - 12405 (2002)

Krojer, T.; Garrido-Franco, M.; Huber, R.; Ehrmann, M.; Clausen, T.: Crystal structure of DegP (HtrA) reveals a new protease- chaperone machine. Nature 416 (6879), pp. 455 - 459 (2002)

Bochtler, M.; Groll, M.; Brandstetter, H.; Clausen, T.; Huber, R.: Molecular machines for protein degradation. Protein Degradation. In: Protein Degradation 1, pp. 248 - 287 (Eds. Mayer, R. J.; A., C.; Rechsteiner, M.). Wiley-VCH, Weinheim (2005)