Publications of F. Ulrich Hartl

Kirstein, J.; Morito, D.; Kakihana, T.; Sugihara, M.; Minnen, A.; Hipp, M. S.; Nussbaum-Krammer, C.; Kasturi, P.; Hartl, F. U.; Nagata, K. et al.; Morimoto, R. I.: Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. EMBO JOURNAL 34 (18), pp. 2334 - 2349 (2015)

Walther, D. M.; Kasturi, P.; Zheng, M.; Pinkert, S.; Vecchi, G.; Ciryam, P.; Morimoto, R. I.; Dobson, C. M.; Vendruscolo, M.; Mann, M. et al.; Hartl, F. U.: Widespread Proteome Remodeling and Aggregation in Aging C-elegans. Cell 161 (4), pp. 919 - 932 (2015)

Hipp, M. S.; Park, S.-H.; Hartl, F. U.: Proteostasis impairment in protein-misfolding and -aggregation diseases. Trends in Cell Biology 24 (9), pp. 506 - 514 (2014)

Georgescauld, F.; Popova, K.; Gupta, A. J.; Bracher, A.; Engen, J. R.; Hayer-Hartl, M.; Hartl, F. U.: GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding. CELL 157 (4), pp. 922 - 934 (2014)

Gupta, A. J.; Haldar, S.; Milicic, G.; Hartl, F. U.; Hayer-Hartl, M.: Active Cage Mechanism of Chaperonin-Assisted Protein Folding Demonstrated at Single-Molecule Level. JOURNAL OF MOLECULAR BIOLOGY 426 (15), pp. 2739 - 2754 (2014)

Leitman, J.; Barak, B.; Benyair, R.; Shenkman, M.; Ashery, U.; Hartl, F. U.; Lederkremer, G. Z.: ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin. PLOS ONE 9 (3), e90803 (2014)

Raychaudhuri, S.; Loew, C.; Körner, R.; Pinkert, S.; Theis, M.; Hayer-Hartl, M.; Buchholz, F.; Hartl, F. U.: Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1. CELL 156 (5), pp. 975 - 985 (2014)

Ripaud, L.; Chumakova, V.; Antonin, M.; Hastie, A. R.; Pinkert, S.; Körner, R.; Ruff, K. M.; Pappu, R. V.; Hornburg, D.; Mann, M. et al.; Hartl, F.-U.; Hipp, M. S.: Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111 (51), pp. 18219 - 18224 (2014)

Vincenz, L.; Hartl, F. U.: Sugarcoating ER Stress. CELL 156 (6), pp. 1125 - 1127 (2014)

Leitman, J.; Hartl, F. U.; Lederkremer, G. Z.: Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress. NATURE COMMUNICATIONS 4, 2753 (2013)

Hartl, F. U.; Hayer-Hartl, M.: THE FIRST CHAPERONIN. NATURE REVIEWS MOLECULAR CELL BIOLOGY 14 (10), pp. 611 - 611 (2013)

Li, Z.; Hartl, F. U.; Bracher, A.: Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle. NATURE STRUCTURAL & MOLECULAR BIOLOGY 20 (8), pp. 929 - 935 (2013)

Park, S.-H.; Kukushkin, Y.; Gupta, R.; Chen, T.; Konagai, A.; Hipp, M. S.; Hayer-Hartl, M.; Hartl, F. U.: PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone. Cell 154 (1), pp. 134 - 145 (2013)

Rüßmann, F.; Stemp, M. J.; Mönkemeyer, L.; Etchells, S. A.; Bracher, A.; Hartl, F.-U.: Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109 (52), pp. 21208 - 21215 (2012)

Herzog, F.; Kahraman, A.; Boehringer, D.; Mak, R.; Bracher, A.; Walzthoeni, T.; Leitner, A.; Beck, M.; Hartl, F.-U.; Ban, N. et al.; Malmstroem, L.; Aebersold, R.: Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry. SCIENCE 337 (6100), pp. 1348 - 1352 (2012)

Tsai, Y. C. C.; Mueller-Cajar, O.; Saschenbrecker, S.; Hartl, F. U.; Hayer-Hartl, M.: Chaperonin Cofactors, Cpn10 and Cpn20, of Green Algae and Plants Function as Hetero-oligomeric Ring Complexes. Journal of Biological Chemistry 287 (24), pp. 20471 - 20481 (2012)

Leitner, A.; Joachimiak, L. A.; Bracher, A.; Mönkemeyer, L.; Walzthoeni, T.; Chen, B.; Pechmann, S.; Holmes, S.; Cong, Y.; Ma, B. X. et al.; Ludtke, S.; Chiu, W.; Hartl, F. U.; Aebersold, R.; Frydman, J.: The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT. Structure 20 (5), pp. 814 - 825 (2012)

Calloni, G.; Chen, T.; Schermann, S. M.; Chang, H.-c.; Genevaux, P.; Agostini, F.; Gaetano Tartaglia, G.; Hayer-Hartl, M.; Hartl, F. U.: DnaK Functions as a Central Hub in the E. coli Chaperone Network. CELL REPORTS 1 (3), pp. 251 - 264 (2012)

Lamond, A. I.; Uhlen, M.; Horning, S.; Makarov, A.; Robinson, C. V.; Serrano, L.; Hartl, F. U.; Baumeister, W.; Werenskiold, A. K.; Andersen, J. S. et al.; Vorm, O.; Linial, M.; Aebersold, R.; Mann, M.: Advancing Cell Biology Through Proteomics in Space and Time (PROSPECTS). Molecular & Cellular Proteomics 11 (Special Issue: Prospects in Space and Time), O112.017731, pp. [1] - [12] (2012)

Sharma, K.; Vabulas, R. M.; Macek, B.; Pinkert, S.; Cox, J.; Mann, M.; Hartl, F. U.: Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response. Special Issue: Prospects in Space and Time, M111.014654, pp. [1] - [12] (2011)