Publications

Kamps, J.; Yuste-Checa, P.; Mamashli, F.; Schmitz, M.; Herrera, M. G.; da Silva Correia, S. M.; Gogte, K.; Bader, V.; Zerr, I.; Hartl, F. U. et al.; Bracher, A.; Winklhofer, K. F.; Tatzelt, J.: Regulated Proteolysis Induces Aberrant Phase Transition of Biomolecular Condensates into Aggregates: A Protective Role for the Chaperone Clusterin. Journal of Molecular Biology 436 (23), 168839 (2024)

Wales, T. E.; Pajak, A.; Roeselova, A.; Shivakumaraswamy, S.; Howell, S.; Kjaer, S.; Hartl, F. U.; Engen, J. R.; Balchin, D.: Resolving chaperone-assisted protein folding on the ribosome at the peptide level. Nature Structural & Molecular Biology 31 (12), pp. 1888 - 1897 (2024)

Wagner, J.; Carvajal, A. I.; Bracher, A.; Beck, F.; Wan, W.; Bohn, S.; Körner, R.; Baumeister, W.; Fernandez-Busnadiego, R.; Hartl, F. U.: Visualizing chaperonin function in situ by cryo-electron tomography. Nature 633 (8029), pp. 459 - 464 (2024)

Cairo, L. V.; Hong, X.; Mueller, M. B. D.; Yuste-Checa, P.; Jagadeesan, C.; Bracher, A.; Park, S.-H.; Hayer-Hartl, M.; Hartl, F. U.: Stress-dependent condensate formation regulated by the ubiquitin-related modifier Urm1. Cell 187 (17), pp. 4656 - 4673.e28 (2024)

Hipp, M. S.; Hartl, F. U.: Interplay of proteostasis capacity and Pprotein aggregation: Implications for cellular function and disease. Journal of Molecular Biology 436 (14), 168615 (2024)

Zhao, D. Y.; Bäuerlein, F. J. B.; Saha, I.; Hartl, F. U.; Baumeister, W.; Wilfling, F.: Autophagy preferentially degrades non-fibrillar polyQ aggregates. Molecular Cell 84 (10), pp. 1980 - 1994 (2024)

Furthmann, N.; Bader, V.; Angersbach, L.; Blusch, A.; Goel, S.; Sanchez-Vicente, A.; Krause, L. J.; Chaban, S. A.; Grover, P.; Trinkaus, V. A. et al.; van Well, E. M.; Jaugstetter, M.; Tschulik, K.; Damgaard, R. B.; Saft, C.; Ellrichmann, G.; Gold, R.; Koch, A.; Englert, B.; Westenberger, A.; Klein, C.; Jungbluth, L.; Sachse, C.; Behrends, C.; Glatzel, M.; Hartl, F. U.; Nakamura, K.; Christine, C. W.; Huang, E. J.; Tatzelt, J.; Winklhofer, K. F.: NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62. Nature Communications 14 (1), 8368 (2023)

Müller, M. B. D.; Kasturi, P.; Jayaraj, G. G.; Hartl, F. U.: Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control. Cell 186 (15), pp. 3227 - 3244 (2023)

Saha, I.; Yuste-Checa, P.; Padilha, M. D. S.; Guo, Q.; Körner, R.; Holthusen, H.; Trinkaus, V. A.; Dudanova, I.; Fernandez-Busnadiego, R.; Baumeister, W. et al.; Sanders, D. W.; Gautam, S.; Diamond, M. I.; Hartl, F. U.; Hipp, M. S.: The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system. Nature Communications 14 (1), 560 (2023)

Gropp, M. H. M.; Klaips, C. L.; Hartl, F. U.: Formation of toxic oligomers of polyQ-expanded Huntingtin by prion-mediated cross-seeding. Molecular Cell 82 (22), pp. 4290 - 4306 (2022)

Yuste-Checa, P.; Bracher, A.; Hartl, F. U.: The chaperone Clusterin in neurodegeneration-friend or foe? Bioessays 44 (7), e2100287 (2022)

Riemenschneider, H.; Guo, Q.; Bader, J.; Frottin, F.; Farny, D.; Kleinberger, G.; Haass, C.; Mann, M.; Hartl, F. U.; Baumeister, W. et al.; Hipp, M. S.; Meissner, F.; Fernandez-Busnadiego, R.; Edbauer, D.: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. EMBO Reports 23 (6), e53890 (2022)

Blumenstock, S.; Schulz-Trieglaff, K.; Voelkl, K.; Bolender, A.-L.; Lapios, P.; Lindner, J.; Hipp, M. S.; Hartl, F. U.; Klein, R.; Dudanova, I.: Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease. EMBO Journal 40 (19), e107260 (2021)

Frottin, F.; Perez-Berlanga, M.; Hartl, F. U.; Hipp, M. S.: Multiple pathways of toxicity induced by c9orf72 dipeptide repeat aggregates and G(4)C(2) RNA in a cellular model. eLife 10, e62718 (2021)

Schneider, M. M.; Gautam, S.; Herling, T. W.; Andrzejewska, E.; Krainer, G.; Miller, A. M.; Trinkaus, V. A.; Peter, Q. A. E.; Ruggeri, F. S.; Vendruscolo, M. et al.; Bracher, A.; Dobson, C. M.; Hartl, F. U.; Knowles, T. P. J.: The Hsc70 disaggregation machinery removes monomer units directly from alpha-synuclein fibril ends. Nature Communications 12 (1), 5999 (2021)

Sitron, C. S.; Hartl, F. U.: A new way of D/Ealing with protein misfolding. Molecular Cell 81 (20), pp. 4114 - 4115 (2021)

Trinkaus, V. A.; Riera-Tur, I.; Martinez Sanchez, A.; Bäuerlein, F. J. B.; Guo, Q.; Arzberger, T.; Baumeister, W.; Dudanova, I.; Hipp, M. S.; Hartl, F. U. et al.; Fernandez-Busnadiego, R.: In situ architecture of neuronal alpha-Synuclein inclusions. Nature Communications 12 (1), 2110 (2021)

Zang, K.; Wang, H.; Hartl, F. U.; Hayer-Hartl, M.: Scaffolding protein CcmM directs multiprotein phase separation in beta-carboxysome biogenesis. Nature Structural and Molecular Biology 28 (11), pp. 909 - 922 (2021)

Zhao, L.; Castanie-Cornet, M.-P.; Kumar, S.; Genevaux, P.; Hayer-Hartl, M.; Hartl, F. U.: Bacterial RF3 senses chaperone function in co-translational folding. Molecular Cell 81 (14), pp. 2914 - 2928 (2021)

Zinzula, L.; Basquin, J.; Bohn, S.; Beck, F.; Klumpe, S.; Pfeifer, G.; Nagy, I.; Bracher, A.; Hartl, F. U.; Baumeister, W.: High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus 2. Biochemical and Biophysical Research Communications 538, pp. 54 - 62 (2021)