Brenda Schulman
Research Department Molecular Machines and Signaling (MoMaS)
Structural Biology, Ubiquitin Proteasome System, Ubiquitin-like Protein
An important form of regulation is the modification of proteins and membranes by linking them to the small protein ubiquitin or structurally related ubiquitin-like proteins (UBLs). Ubiquitin and UBLs control timing, subcellular location, composition, conformation and activity of thousands of different proteins and macromolecules. In addition, defects in ubiquitin and UBL pathways are associated with numerous diseases such as cancer, neurodegenerative disorders and viral infections. Brenda Schulman's Department “Molecular Machines and Signaling” has shown that hundreds of microscopic, dynamic, multiprotein molecular machines are transiently transformed into different conformations by specialized regulatory factors to control ubiquitin and UBLs in order to regulate virtually all aspects of cell biology.
A widespread mechanism regulating the functions of eukaryotic proteins involves post-translational modification by the small protein ubiquitin (UB) or structurally related ubiquitin-like proteins (UBLs).
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Department News
New Publication in Nature: Great collaboration! Congratulations to MoMaS members Lukas, Jakob, and Viola for discovering stress induction of FBXO31 by our active E3 ligase profiling! Big congrats to Jakob Farnung, Matthias Muhar, Jeff Bode, Jacob Corn, and all authors for this outstanding work!
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New Publication in Science Advances: Great collaboration, and congratulations to Felix Kraus, ASAP Team Harper, Coon and Harper labs and all authors! Kudos to MoMaS members past and present Cristina, Anna, and Florian for outstanding contributions and awesome collaboration with Plitzko for this outstanding study!
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Feldberg Prize 2025 for Anglo-German scientific exchange is awarded to scientists in Germany and Britain annually for their outstanding achievements in their fields. Congratulations Brenda!
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