Marion Schuller

Research Group Host defence mechanisms

Bacteriophage-Host interaction, ADP-ribosylation signalling, Biochemistry, Structural Biology, Microbiology

I will start my research activities in Martinsried on July 1, 2025.

I am looking for new employees for my team. Please contact me!

Antimicrobial resistance presents a major healthcare threat for which therapeutic solutions are urgently needed. Bacteriophages (phages) are viruses that specifically infect and replicate within bacteria, making phage-inspired therapies a promising approach for combating multidrug-resistant bacterial infections. The interplay between phages and bacteria involves a complex and specific repertoire of immune mechanisms to infect and defend, respectively. Among those strategies is ADP-ribosylation signalling: While ADP-ribose-derived molecules are involved in activation of bacterial effectors, ADP-ribosyl moieties attached to proteins or nucleic acids interfere with viral replication processes and host biosynthetic pathways.

Our group studies the mechanisms and physiological role of ADP-ribosylation signalling in the conflict between phages and the bacterial host to discover novel antimicrobial drug targets and to develop biotechnological approaches including for phage-derived therapies.

 

 

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