Publications of Brenda Schulman

Muhar, M. F.; Farnung, J.; Cernakova, M.; Hofmann, R.; Henneberg, L. T.; Pfleiderer, M. M.; Denoth-Lippuner, A.; Kalčic, F.; Nievergelt, A. S.; Peters Al-Bayati, M. et al.; Sidiropoulos, N. D.; Beier, V.; Mann, M.; Jessberger, S.; Jinek, M.; Schulman, B.; Bode, J. W.; Corn, J. E.: C-terminal amides mark proteins for degradation via SCF–FBXO31. Nature 638, pp. 519 - 527 (2025)

Alkhalaf, L. M.; Arrowsmith, C.; Balskus, E. P.; Bergamini, G.; Bhandari, R.; Chang, C. J.; Chen, P.; Chen, X.; Ciulli, A.; Cricco, J. A. et al.; Davis, B. G.; Delbianco, M.; Dudareva, N.; Dueber, E.; Ferguson, F.; de Giuseppe, P. O.; Hamachi, I.; Hammond, M. C.; Hatzios, S. K.; Do Heo, W.; Janet, J. P.; Kamat, S. S.; Knapp, S.; Krishnan, Y.; Lang, K.; Laraia, L.; Leveson-Gower, R. B.; Li, X. D.; Liu, D. R.; Liu, M.-F.; London, N.; Mahanta, N.; Mayor-Ruiz, C.; Muir, T.; Murakami, M. T.; Rhee, H.-W.; Robers, M.; Satz, A.; Schulman, B. A.; Shen, B.; Shoichet, B.; Strauss, E.; Suzuki, T.; Tiwary, P.; Waldmann, H.; Ward, T. R.; Weeks, A.; Weerapana, E.; Winter, G.: Thoughts for the future. Nature Chemical Biology 21, pp. 6 - 15 (2025)

Scott, D. C.; Chittori, S.; Purser, N.; King, M. T.; Maiwald, S. A.; Churion, K.; Nourse, A.; Lee, C.; Paulo, J. A.; Miller, D. J. et al.; Elledge, S. J.; Harper, J. W.; Kleiger, G.; Schulman, B. A.: Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases. Nature Communications 15 (1), 9899 (2024)

Farnung, J.; Schulman, B. A.: Ubiquitin is a chemist's playground. Nature Chemistry 16 (11), 1918 (2024)

Scott, D. C.; Dharuman, S.; Griffith, E.; Chai, S. C.; Ronnebaum, J.; King, M. T.; Tangallapally, R.; Lee, C.; Gee, C. T.; Yang, L. et al.; Li, Y.; Loudon, V. C.; Lee, H. W.; Ochoada, J.; Miller, D. J.; Jayasinghe, T.; Paulo, J. A.; Elledge, S. J.; Harper, J. W.; Chen, T.; Lee, R. E.; Schulman, B. A.: Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nature Communications 15, 8829 (2024)

Adolf, F.; Du, J.; Goodall, E. A.; Walsh Jr, R. M.; Rawson, S.; Gronau, S. v.; Harper, J. W.; Hanna, J.; Schulman, B. A.: Visualizing chaperone-mediated multistep assembly of the human 20S proteasome. Nature Structural & Molecular Biology 31 (8), pp. 1176 - 1188 (2024)

Horn-Ghetko, D.; Hopf, L. V. M.; Tripathi-Giesgen, I.; Du, J.; Kostrhon, S.; Tung Vu, D.; Beier, V.; Steigenberger, B.; Prabu, J. R.; Stier, L. et al.; Bruss, E. M.; Mann, M.; Xiong, Y.; Schulman, B. A.: Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex. Nature Structural & Molecular Biology 31 (7), pp. 1083 - 1094 (2024)

Kagiou, C.; Cisneros, J. A.; Farnung, J.; Liwocha, J.; Offensperger, F.; Dong, K.; Yang, K.; Tin, G.; Horstmann, C. S.; Hinterndorfer, M. et al.; Paulo, J. A.; Scholes, N. S.; Sanchez Avila, J.; Fellner, M.; Andersch, F.; Hannich, J. T.; Zuber, J.; Kubicek, S.; Gygi, S. P.; Schulman, B. A.; Winter, G. E.: Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation. Nature Communications 15 (1), 5409 (2024)

Yi, S. A.; Sepic, S.; Schulman, B. A.; Ordureau, A.; An, H.: mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway. Molecular Cell 84 (11), pp. 2166 - 2184 (2024)

Gottemukkala, K. V.; Chrustowicz, J.; Sherpa, D.; Sepic, S.; Tung Vu, D.; Karayel, O.; Papadopoulou, E. C.; Gross, A.; Schorpp, K.; von Gronau, S. et al.; Hadian, K.; Murray, P. J.; Mann, M.; Schulman, B. A.; Alpi, A. F.: Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. Molecular Cell 84 (10), pp. 1948 - 1963.e11 (2024)

Gross, A.; Müller, J.; Chrustowicz, J.; Strasser, A.; Gottemukkala, K. V.; Sherpa, D.; Schulman, B. A.; Murray, P. J.; Alpi, A. F.: Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly. FEBS Letters 598 (9), pp. 978 - 994 (2024)

Li, J.; Purser, N.; Liwocha, J.; Scott, D. C.; Byers, H. A.; Steigenberger, B.; Hill, S.; Tripathi-Giesgen, I.; Hinkle, T.; Hansen, F. M. et al.; Prabu, J. R.; Radhakrishnan, S. K.; Kirkpatrick, D. S.; Reichermeier, K. M.; Schulman, B. A.; Kleiger, G.: Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Molecular Cell 84 (7), pp. 1304 - 1320 (2024)

Hoyer, M. J.; Capitanio, C.; Smith, I. R.; Paoli, J. C.; Bieber, A.; Jiang, Y.; Paulo, J. A.; Gonzalez-Lozano, M. A.; Baumeister, W.; Wilfling, F. et al.; Schulman, B. A.; Harper, J. W.: Combinatorial selective ER-phagy remodels the ER during neurogenesis. Nature Cell Biology 26, pp. 378 - 392 (2024)

Liwocha, J.; Li, J.; Purser, N.; Rattanasopa, C.; Maiwald, S.; Krist, D. T.; Scott, D. C.; Steigenberger, B.; Prabu, J. R.; Schulman, B. A. et al.; Kleiger, G.: Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases. Nature Structural & Molecular Biology 31 (2), pp. 378 - 389 (2024)

Hehl, L. A.; Horn-Ghetko, D.; Prabu, J. R.; Vollrath, R.; Tung Vu, D.; Pérez Berrocal, D. A.; Mulder, M. P. C.; van der Heden van Noort, G. J.; Schulman, B. A.: Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5. Nature Chemical Biology 20, pp. 190 - 200 (2024)

Chrustowicz, J.; Sherpa, D.; Li, J.; Langlois, C. R.; Papadopoulou, E. C.; Tung Vu, D.; Hehl, L. A.; Karayel, Ö.; Beier, V.; Gronau, S. v. et al.; Müller, J.; Prabu, J. R.; Mann, M.; Kleiger, G.; Alpi, A. F.; Schulman, B. A.: Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Molecular Cell 84 (2), pp. 293 - 308 (2024)

Botsch, J. J.; Junker, R.; Sorgenfrei, M.; Ogger, P. P.; Stier, L.; von Gronau, S.; Murray, P. J.; Seeger, M. A.; Schulman, B. A.; Bräuning, B.: Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nature Communications 15 (1), 410 (2024)

Lewis, S. C.; Jourdain, A. A.; Schulman, B. A.; Vousden, K. H.; Fabius, J. M.; Liu, H.: Recovering from the stress of the COVID-19 pandemic. Molecular Cell 84 (1), pp. 8 - 11 (2024)

Wallace, I.; Baek, K.; Prabu, J. R.; Vollrath, R.; von Gronau, S.; Schulman, B. A.; Swatek, K. N.: Insights into the ISG15 transfer cascade by the UBE1L activating enzyme. Nature Communications 14 (1), 7970 (2023)

Henneberg, L. T.; Singh, J.; Duda, D. M.; Baek, K.; Yanishevski, D.; Murray, P. J.; Mann, M.; Sidhu, S. S.; Schulman, B. A.: Activity-based profiling of cullin-RING E3 networks by conformation-specific probes. Nature Chemical Biology 19, pp. 1513 - 1523 (2023)