Publications of Frederic Frottin

Riemenschneider, H.; Guo, Q.; Bader, J. M.; Frottin, F.; Farny, D.; Kleinberger, G.; Haass, C.; Mann, M.; Hartl, F. U.; Baumeister, W. et al.; Hipp, M. S.; Meissner, F.; Fernandez-Busnadiego, R.; Edbauer, D.: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. EMBO Reports 23 (6), e53890 (2022)

Frottin, F.; Perez-Berlanga, M.; Hartl, F. U.; Hipp, M. S.: Multiple pathways of toxicity induced by c9orf72 dipeptide repeat aggregates and G(4)C(2) RNA in a cellular model. eLife 10, e62718 (2021)

Khosravi, B.; LaClair, K. D.; Riemenschneider, H.; Zhou, Q.; Frottin, F.; Mareljic, N.; Czuppa, M.; Farny, D.; Hartmann, H.; Michaelsen, M. et al.; Arzberger, T.; Hartl, F. U.; Hipp, M. S.; Edbauer, D.: Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD. EMBO JOURNAL 39 (8), e102811 (2020)

Frottin, F.; Schueder, F.; Tiwary, S.; Gupta, R.; Körner, R.; Schlichthaerle, T.; Cox, J.; Jungmann, R.; Hartl, F. U.; Hipp, M. S.: The nucleolus functions as a phase-separated protein quality control compartment. Science 365 (6451), pp. 342 - 347 (2019)

Guo, Q.; Lehmer, C.; Martinez Sanchez, A.; Rudack, T.; Beck, F.; Hartmann, H.; Perez-Berlanga, M.; Frottin, F.; Hipp, M. S.; Hartl, F. U. et al.; Edbauer, D.; Baumeister, W.; Fernandez-Busnadiego, R.: In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell 172 (4), pp. 696 - 705.e12 (2018)

Kim, Y. E.; Hosp, F.; Frottin, F.; Ge, H.; Mann, M.; Hayer-Hartl, M.; Hartl, F. U.: Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors. Molecular Cell 63 (6), pp. 951 - 964 (2016)

Woerner, A. C.; Frottin, F.; Hornburg, D.; Feng, L. R.; Meissner, F.; Patra, M.; Tatzelt, J.; Mann, M.; Winklhofer, K. F.; Hartl, F. U. et al.; Hipp, M. S.: Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA. Science 351 (6269), pp. 173 - 176 (2016)

Frottin, F.; Bienvenut, W. V.; Bignon, J.; Jacquet, E.; Jacome, A. S. V.; Van Dorsselaer, A.; Cianferani, S.; Carapito, C.; Meinnel, T.; Giglione, C.: MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state. Oncotarget 7 (39), pp. 63306 - 63323 (2016)