Publications of R. Friedrich

Friedrich, R.; Riester, D.; Göttig, P.; Thurk, M.; Schwienhorst, A.; Bode, W.: Structure of a novel thrombin inhibitor with an uncharged D-amino acid as P1 residue. European Journal of Medicinal Chemistry 43 (6), pp. 1330 - 1335 (2008)

Mlinsek, G.; Friedrich, R.; Solmajer, T.: Thrombin Inhibitors With Novel Azaphenylalanine Scaffolds and a New P1 Binding Pocket Functionality: Structural Analysis of Binding. Acta Chimica Slovenica 55 (4), pp. 739 - 751 (2008)

Debela, M.; Magdolen, V.; Grimminger, V.; Sommerhoff, C.; Messerschmidt, A.; Huber, R.; Friedrich, R.; Bode, W.; Goettig, P.: Crystal structures of human tissue kallikrein 4: Activity modulation by a specific zinc binding site. Journal of Molecular Biology 362 (5), pp. 1094 - 1107 (2006)

Steinmetzer, T.; Schweinitz, A.; Sturzebecher, A.; Donnecke, D.; Uhland, K.; Schuster, O.; Steinmetzer, P.; Muller, F.; Friedrich, R.; Than, M. E. et al.; Bode, W.; Sturzbecher, J.: Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. Journal of Medicinal Chemistry 49 (14), pp. 4116 - 4126 (2006)

Friedrich, R.; Panizzi, P.; Kawabata, S. I.; Bode, W.; Bock, P. E.; Fuentes-Prior, P.: Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation. Journal of Biological Chemistry 281 (2), pp. 1188 - 1195 (2006)

Panizzi, P.; Friedrich, R.; Prior, P. F.; Kroh, H. K.; Briggs, J.; Tans, G.; Bode, W.; Bock, P. E.: Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactions. Journal of Biological Chemistry 281 (2), pp. 1169 - 1178 (2006)

Panizzi, P.; Friedrich, R.; Prior, P. F.; Richter, K.; Bock, P. E.; Bode, W.: Fibrinogen substrate recognition by Staphylocoagulase center dot(pro) thrombin complexes. Journal of Biological Chemistry 281 (2), pp. 1179 - 1187 (2006)

Riester, D.; Wirsching, F.; Salinas, G.; Keller, M.; Gebinoga, M.; Kamphausen, S.; Merkwirth, C.; Goetz, R.; Wiesenfeldt, M.; Sturzebecher, J. et al.; Bode, W.; Friedrich, R.; Thurk, M.; Schwienhorst, A.: Thrombin inhibitors identified by computer-assisted multiparameter design. Proceedings of the National Academy of Sciences of the United States of America 102 (24), pp. 8597 - 8602 (2005)

Pal, P. P.; Bae, J. H.; Azim, M. K.; Hess, P.; Friedrich, R.; Huber, R.; Moroder, L.; Budisa, N.: Structural and spectral response of Aequorea victoria green fluorescent proteins to chromophore fluorination. Biochemistry 44 (10), pp. 3663 - 3672 (2005)

Panizzi, P.; Friedrich, R.; Fuentes-Prior, P.; Bode, W.; Bock, P. E.: The staphylocoagulase family of zymogen activator and adhesion proteins. Cellular and Molecular Life Sciences 61 (22), pp. 2793 - 2798 (2004)

Friedrich, R.; Panizzi, P.; Fuentes-Prior, P.; Richter, K.; Verhamme, I.; Anderson, P. J.; Kawabata, S. I.; Huber, R.; Bode, W.; Bock, P. E.: Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation. Nature 425 (6957), pp. 535 - 539 (2003)

Friedrich, R.; Steinmetzer, T.; Huber, R.; Stürzebecher, J.; Bode, W.: The methyl group of N-alpha(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage. Journal of Molecular Biology 316 (4), pp. 869 - 874 (2002)

Friedrich, R.; Fuentes-Prior, P.; Ong, E.; Coombs, G.; Hunter, M.; Oehler, R.; Pierson, D.; Gonzalez, R.; Huber, R.; Bode, W. et al.; Madison, E. L.: Catalytic domain structures of MT-SP1/matriptase, a matrix- degrading transmembrane serine proteinase. Journal of Biological Chemistry 277 (3), pp. 2160 - 2168 (2002)

Moroder, L.; Fiori, S.; Friedrich, R.; Müller, J.C.D.; Ottl, J.: Collagen mimics. Synthesis and properties of disulfide-bridged trimeric collagen peptides. In: Synthetic Macromolecules with Higher Structural Order, pp. 103 - 116 (Ed. Khan, I.M.). ACS, Washington, DC (2002)

Friedrich, R.: Kristallographische und biophysikalische Untersuchungen an Serinproteinase-Effektor-Komplexen. Dissertation, Technische Universität, München (2001)