Publications of Arno F. Alpi

Gottemukkala, K. V.; Chrustowicz, J.; Sherpa, D.; Sepic, S.; Tung Vu, D.; Karayel, O.; Papadopoulou, E. C.; Gross, A.; Schorpp, K.; von Gronau, S. et al.; Hadian, K.; Murray, P. J.; Mann, M.; Schulman, B. A.; Alpi, A. F.: Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. Molecular Cell 84 (10), pp. 1948 - 1963.e11 (2024)

Gross, A.; Müller, J.; Chrustowicz, J.; Strasser, A.; Gottemukkala, K. V.; Sherpa, D.; Schulman, B. A.; Murray, P. J.; Alpi, A. F.: Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly. FEBS Letters 598 (9), pp. 978 - 994 (2024)

Chrustowicz, J.; Sherpa, D.; Li, J.; Langlois, C. R.; Papadopoulou, E. C.; Tung Vu, D.; Hehl, L. A.; Karayel, Ö.; Beier, V.; Gronau, S. v. et al.; Müller, J.; Prabu, J. R.; Mann, M.; Kleiger, G.; Alpi, A. F.; Schulman, B. A.: Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Molecular Cell 84 (2), pp. 293 - 308 (2024)

Purser, N.; Tripathi-Giesgen, I.; Li, J.; Scott, D. C.; Horn-Ghetko, D.; Baek, K.; Schulman, B. A.; Alpi, A. F.; Kleiger, G.: Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase. Biochemical Journal 480 (22), pp. 1817 - 1831 (2023)

Sherpa, D.; Mueller, J.; Karayel, Ö.; Xu, P.; Yao, Y.; Chrustowicz, J.; Gottemukkala, K. V.; Baumann, C. A.; Gross, A.; Czarnecki, O. et al.; Zhang, W.; Gu, J.; Nilvebrant, J.; Sidhu, S. S.; Murray, P. J.; Mann, M.; Weiss, M. J.; Schulman, B. A.; Alpi, A. F.: Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation. eLife 11, e77937 (2022)

Kostrhon, S.; Prabu, J. R.; Baek, K.; Horn-Ghetko, D.; Gronau, S. v.; Klügel, M.; Basquin, J.; Alpi, A. F.; Schulman, B. A.: CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation. Nature Chemical Biology 17 (10), pp. 1075 - 1083 (2021)

Sherpa, D.; Chrustowicz, J.; Qiao, S.; Langlois, C. R.; Hehl, L. A.; Gottemukkala, K. V.; Hansen, F. M.; Karayel, O.; von Gronau, S.; Prabu, J. R. et al.; Mann, M.; Alpi, A. F.; Schulman, B. A.: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Molecular Cell 81 (11), pp. 2445 - 2459.e13 (2021)

Tripathi-Giesgen, I.; Behrends, C.; Alpi, A. F.: The ubiquitin ligation machinery in the defense against bacterial pathogens. EMBO Reports 22 (11), e52864 (2021)

Xu, P.; Scott, D. C.; Xu, B.; Yao, Y.; Feng, R.; Cheng, L.; Mayberry, K.; Wang, Y.-D.; Bi, W.; Palmer, L. E. et al.; King, M. T.; Wang, H.; Li, Y.; Fan, Y.; Alpi, A. F.; Li, C.; Peng, J.; Papizan, J.; Pruett-Miller, S. M.; Spallek, R.; Bassermann, F.; Cheng, Y.; Schulman, B.; Weiss, M. J.: FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis. Blood 137, pp. 155 - 167 (2021)

Karayel, Ö.; Xu, P.; Bludau, I.; Velan Bhoopalan, S.; Yao, Y.; Ana Rita, F.C.; Santos, A.; Schulman, B. A.; Alpi, A. F.; Weiss, M.J. et al.; Mann, M.: Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis. Molecular Systems Biology 16 (12), e9813 (2020)

Qiao, S.; Langlois, C. R.; Chrustowicz, J.; Sherpa, D.; Karayel, O.; Hansen, F. M.; Beier, V.; von Gronau, S.; Bollschweiler, D.; Schäfer, T. et al.; Alpi, A. F.; Mann, M.; Prabu, J. R.; Schulman, B.: Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. MOLECULAR CELL 77 (1), pp. 150 - 163.e9 (2020)

Huttenhain, R.; Xu, J.; Burton, L. A.; Gordon, D. E.; Hultquist, J. F.; Johnson, J. R.; Satkamp, L.; Hiatt, J.; Rhee, D. Y.; Baek, K. et al.; Crosby, D. C.; Frankel, A. D.; Marson, A.; Harper, J. W.; Alpi, A. F.; Schulman, B. A.; Gross, J. D.; Krogan, N. J.: ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host & Microbe 26 (1), pp. 86 - 99.e7 (2019)

Kelsall, I. R.; Kristariyanto, Y. A.; Knebel, A.; Wood, N. T.; Kulathu, Y.; Alpi, A. F.: Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling. Journal of Biological Chemistry 294 (8), pp. 2651 - 2664 (2019)

Scott, D. C.; Hammill, J. T.; Min, J.; Rhee, D. Y.; Connelly, M.; Sviderskiy, V. O.; Bhasin, D.; Chen, Y.; Ong, S.-S.; Chai, S. C. et al.; Goktug, A. N.; Huang, G.; Monda, J. K.; Low, J.; Kim, H. S.; Paulo, J. A.; Cannon, J. R.; Shelat, A. A.; Chen, T.; Kelsall, I. R.; Alpi, A. F.; Pagala, V.; Wang, X.; Peng, J.; Singh, B.; Harper, J. W.; Schulman, B. A.; Guy, R. K.: Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nature Chemical Biology 13 (8), pp. 850 - 857 (2017)

Wicky, C.; Alpi, A.; Passannante, M.; Rose, A.; Gartner, A.; Muller, F.: Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-5.1, and top-3 are needed to maintain genome stability in the germ line. Molecular and Cellular Biology 24 (11), pp. 5016 - 5027 (2004)

Schumacher, B.; Alpi, A.; Gartner, A.: Cell cycle: Check for asynchrony. Current Biology 13 (14), pp. R560 - R562 (2003)

Schumacher, B.; Alpi, A.; Wittenburg, N.; Boulton, S.; Hofmann, K.; Saham, S.; Vidal, M.; Conradt, B.; Gartner, A.: The roads to death, DNA damage induced apoptosis in the C. elegans germline. European Journal of Cell Biology 82 (Suppl. Suppl. 53), p. 56 - 56 (2003)

Alpi, A.; Pasierbek, P.; Gartner, A.; Loidl, J.: Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans. Chromosoma 112 (1), pp. 6 - 16 (2003)

Ahmed, S.; Alpi, A.; Hengartner, M. O.; Gartner, A.: C-elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Current Biology 11 (24), pp. 1934 - 1944 (2001)

Alpi, A. F.; Echalier, A.: ZOMES: the intriguing interplay of PCI complexes and the ubiquitin in protein homeostasis. ZOMES IX conference “PCI complexes and ubiquitin defining a hub for protein homeostasis”, Rome, Italy, February 14, 2017 - February 17, 2017. Cell Death and Disease 8, e3021, (2017)