Publications of J. C. Young

Shomura, Y.; Dragovic, Z.; Chang, H. C.; Tzvetkov, N.; Young, J. C.; Brodsky, J. L.; Guerriero, V.; Hartl, F. U.; Bracher, A.: Regulation of Hsp70 function by HspBP1: Structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. Molecular Cell 17 (3), pp. 367 - 379 (2005)

Young, J. C.; Agashe, V. R.; Siegers, K.; Hartl, F. U.: Pathways of chaperone-mediated protein folding in the cytosol. Nature Reviews Molecular Cell Biology 5 (10), pp. 781 - 791 (2004)

Wochnik, G. M.; Young, J. C.; Schmidt, U.; Holsboer, F.; Hartl, F. U.; Rein, T.: Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90. FEBS Letters 560 (1-3), pp. 35 - 38 (2004)

Young, J.: The chaperone/Tom70 mitochondrial targeting pathway. Biochimica et Biophysica Acta-Bioenergetics 1657 (Suppl. Suppl. 1), pp. 13 - 14 (2004)

Rosenhagen, M. C.; Soti, C.; Schmidt, U.; Wochnik, G. M.; Hartl, F. U.; Holsboer, F.; Young, J. C.; Rein, T.: The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation. Molecular Endocrinology 17 (10), pp. 1991 - 2001 (2003)

Young, J. C.; Barral, J. M.; Hartl, F. U.: More than folding: localized functions of cytosolic chaperones. Trends in Biochemical Sciences 28 (10), pp. 541 - 547 (2003)

Brychzy, A.; Rein, T.; Winklhofer, K. F.; Hartl, F. U.; Young, J. C.; Obermann, W. M. J.: Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO Journal 22 (14), pp. 3613 - 3623 (2003)

Young, J. C.; Hartl, F. U.: A stress sensor for the bacterial periplasm. Cell 113 (1), pp. 1 - 2 (2003)

Schmidt, U.; Wochnik, G. M.; Rosenhagen, M. C.; Young, J. C.; Hartl, F. U.; Holsboer, F.; Rein, T.: Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor. Journal of Biological Chemistry 278 (7), pp. 4926 - 4931 (2003)

Young, J. C.; Hoogenraad, N. J.; Hartl, F. U.: Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell 112 (1), pp. 41 - 50 (2003)

Sondermann, H.; Ho, A. K.; Listenberger, L. L.; Siegers, K.; Moarefi, I.; Wente, S. R.; Hartl, F. U.; Young, J. C.: Prediction of novel bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae. Journal of Biological Chemistry 277 (36), pp. 33220 - 33227 (2002)

Young, J. C.; Hartl, F. U.: Chaperones and transcriptional regulation by nuclear receptors. Nature Structural Biology 9 (9), pp. 640 - 642 (2002)