Publications of Siglinde Wolf

Boltjes, A.; Huang, Y.; van de Velde, R.; Rijkee, L.; Wolf, S.; Gaugler, J.; Lesniak, K.; Guzik, K.; Holak, T. A.; Dömling, A.: Fragment-Based Library Generation for the Discovery of a Peptidomimetic p53-Mdm4 Inhibitor. ACS COMBINATORIAL SCIENCE 16 (8), pp. 393 - 396 (2014)

Huang, Y.; Wolf, S.; Beck, B.; Koehler, L.-M.; Khoury, K.; Popowicz, G. M.; Goda, S. K.; Subklewe, M.; Twarda, A.; Holak, T. et al.; Domling, A.: Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities. ACS CHEMICAL BIOLOGY 9 (3), pp. 802 - 811 (2014)

Bista, M.; Wolf, S.; Khoury, K.; Kowalska, K.; Huang, Y.; Wrona, E.; Arciniega, M.; Popowicz, G. M.; Holak, T.; Domling, A.: Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction. STRUCTURE 21 (12), pp. 2143 - 2151 (2013)

Wang, W.; Cao, H.; Wolf, S.; Camacho-Horvitz, M. S.; Holak, T.; Domling, A.: Benzimidazole-2-one: A novel anchoring principle for antagonizing p53-Mdm2. BIOORGANIC & MEDICINAL CHEMISTRY 21 (14), pp. 3982 - 3995 (2013)

Koes, D.; Khoury, K.; Huang, Y. J.; Wang, W.; Bista, M.; Popowicz, G. M.; Wolf, S.; Holak, T. A.; Domling, A.; Camacho, C. J.: Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists. PLoS ONE 7 (3), e32839, pp. [1] - [8] (2012)

Huang, Y. J.; Wolf, S.; Koes, D.; Popowicz, G. M.; Camacho, C. J.; Holak, T. A.; Domling, A.: Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists. ChemMedChem 7 (1), pp. 49 - 52 (2012)

Gormanns, P.; Mueller, N. S.; Ditzen, C.; Wolf, S.; Holsboer, F.; Turck, C. W.: Phenome-transcriptome correlation unravels anxiety and depression related pathways. Journal of Psychiatric Research 45 (7), pp. 973 - 979 (2011)

Huang, Y. J.; Wolf, S.; Bista, M.; Meireles, L.; Camacho, C.; Holak, T. A.; Domling, A.: 1,4-Thienodiazepine-2,5-diones via MCR (I): Synthesis, Virtual Space and p53-Mdm2 Activity. Chemical Biology & Drug Design 76 (2), pp. 116 - 129 (2010)

Popowicz, G. M.; Czarna, A.; Wolf, S.; Wang, K.; Wang, W.; Domling, A.; Holak, T. A.: Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle 9 (6), pp. 1104 - 1111 (2010)

Czarna, A.; Beck, B.; Srivastava, S.; Popowicz, G. M.; Wolf, S.; Huang, Y. J.; Bista, M.; Holak, T. A.; Domling, A.: Robust Generation of Lead Compounds for Protein-Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists. Angewandte Chemie-International Edition 49 (31), pp. 5352 - 5356 (2010)

Czarna, A.; Popowicz, G. M.; Pecak, A.; Wolf, S.; Dubin, G.; Holak, T. A.: High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle 8 (8), pp. 1176 - 1184 (2009)

Wolf, S.; Nagy, I.; Lupas, A.; Pfeifer, G.; Cejka, Z.; Müller, S. A.; Engel, A.; Demot, R.; Baumeister, W.: Characterization of arc, a divergent member of the aaa atpase family from rhodococcus erythropolis. Journal of Molecular Biology 277 (1), pp. 13 - 25 (1998)

Lupas, A.; Zühl, F.; Tamura, T.; Wolf, S.; Nagy, I.; Demot, R.; Baumeister, W.: Eubacterial proteasomes. Molecular Biology Reports 24 (1-2), pp. 125 - 131 (1997)

Wolf, S.; Lottspeich, F.; Baumeister, W.: Ubiquitin found in the archaebacterium Thermoplasma acidophilum. FEBS Letters. 326 (1-3), pp. 42 - 44 (1993)

Wolf, S.: Targeting the p53-MDM2 and p53-MDMX interaction as a therapeutic strategy for anticancer treatment. Dissertation, Technische Universität, München (2012)