Publications of R. Huber

Tennstaedt, A.; Popsel, S.; Truebestein, L.; Hauske, P.; Brockmann, A.; Schmidt, N.; Irle, I.; Sacca, B.; Niemeyer, C. M.; Brandt, R. et al.; Ksiezak-Reding, H.; Tirniceriu, A. L.; Egensperger, R.; Baldi, A.; Dehmelt, L.; Kaiser, M.; Huber, R.; Clausen, T.; Ehrmann, M.: Human High Temperature Requirement Serine Protease A1 (HTRA1) Degrades Tau Protein Aggregates. Journal of Biological Chemistry 287 (25), pp. 20931 - 20941 (2012)

Weski, J.; Meltzer, M.; Spaan, L.; Monig, T.; Oeljeklaus, J.; Hauske, P.; Vouilleme, L.; Volkmer, R.; Boisguerin, P.; Boyd, D. et al.; Huber, R.; Kaiser, M.; Ehrmann, M.: Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ Protease. ChemBioChem 13 (3), pp. 402 - 408 (2012)

Baek, S.; Kutchukian, P. S.; Verdine, G. L.; Huber, R.; Holak, T. A.; Lee, K. W.; Popowicz, G. M.: Structure of the Stapled p53 Peptide Bound to Mdm2. Journal of the American Chemical Society 134 (1), pp. 103 - 106 (2012)

Gallastegui, N.; Beck, P.; Arciniega, M.; Huber, R.; Hillebrand, S.; Groll, M.: Hydroxyureas as Noncovalent Proteasome Inhibitors. Angewandte Chemie-International Edition 51 (1), pp. 247 - 249 (2012)

Stubbs, M. T.; Baumann, U.: No end in sight: the development of protein crystallography in Martinsried [Guest Editorial]. Biological Chemistry Hoppe-Seyler (Berlin) 393 (Special Issue), pp. 1025 - 1200 (2012)

Sitar, T.; Gallinger, J.; Ducka, A. M.; Ikonen, T. P.; Wohlhoefler, M.; Schmoller, K. M.; Bausch, A. R.; Joel, P.; Trybus, K. M.; Noegel, A. A. et al.; Schleicher, M.; Huber, R.; Holak, T. A.: Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly. Proceedings of the National Academy of Sciences of the United States of America 108 (49), pp. 19575 - 19580 (2011)

Schneider, E. V.; Bottcher, J.; Blaesse, M.; Neumann, L.; Huber, R.; Maskos, K.: The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder. Journal of Molecular Biology 412 (2), pp. 251 - 266 (2011)

Clausen, T.; Kaiser, M.; Huber, R.; Ehrmann, M.: HTRA proteases: regulated proteolysis in protein quality control. Nature Reviews Molecular Cell Biology 12 (3), pp. 152 - 162 (2011)

Gräwert, M. A.; Gallastegui, N.; Stein, M.; Schmidt, B.; Kloetzel, P. M.; Huber, R.; Groll, M.: Elucidation of the alpha-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition. Angewandte Chemie-International Edition 50 (2), pp. 542 - 544 (2011)

Merdanovic, M.; Clausen, T.; Kaiser, M.; Huber, R.; Ehrmann, M.: Protein Quality Control in the Bacterial Periplasm. Annual Review of Microbiology 65, pp. 149 - 168 (2011)

Groll, M.; Gallastegui, N.; Marechal, X.; Le Ravalec, V.; Basse, N.; Richy, N.; Genin, E.; Huber, R.; Moroder, L.; Vidal, J. et al.; Reboud-Ravaux, M.: 20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A. ChemMedChem 5 (10), pp. 1701 - 1705 (2010)

Clerc, J.; Schellenberg, B.; Groll, M.; Bachmann, A. S.; Huber, R.; Dudler, R.; Kaiser, M.: Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors. European Journal of Organic Chemistry (21), pp. 3991 - 4003 (2010)

Krojer, T.; Sawa, J.; Huber, R.; Clausen, T.: HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues. Nature Structural & Molecular Biology 17 (7), pp. 844 - 852 (2010)

Merdanovic, M.; Mamant, N.; Meltzer, M.; Poepsel, S.; Auckenthaler, A.; Melgaard, R.; Hauske, P.; Nagel-Steger, L.; Clarke, A. R.; Kaiser, M. et al.; Huber, R.; Ehrmann, M.: Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nature Structural & Molecular Biology 17 (7), pp. 837 - 843 (2010)

Ducka, A. M.; Joel, P.; Popowicz, G. M.; Trybus, K. M.; Schleicher, M.; Noegel, A. A.; Huber, R.; Holak, T. A.; Sitar, T.: Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proceedings of the National Academy of Sciences of the United States of America 107 (26), pp. 11757 - 11762 (2010)

Hasenbein, S.; Meltzer, M.; Hauske, P.; Kaiser, M.; Huber, R.; Clausen, T.; Ehrmann, M.: Conversion of a Regulatory into a Degradative Protease. Journal of Molecular Biology 397 (4), pp. 957 - 966 (2010)

Groll, M.; Gallastegui, N.; Maréchal, X.; Le Ravalec, V.; Basse, N.; Richy, N.; Genin, E.; Huber, R.; Moroder, L.; Vidal, J. et al.; Reboud-Ravaux, M.: 20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A. ChemMedChem 5, pp. 1701 - 1705 (2010)

Huber, R.: Nobelpreisträger im Gespräch: Ich bin ins Innere der Moleküle gestiegen. Kontaktum Magazin 2, pp. 6 - 11 (2010)

Clerc, J.; Florea, B. I.; Kraus, M.; Groll, M.; Huber, R.; Bachmann, A. S.; Dudler, R.; Driessen, C.; Overkleeft, H. S.; Kaiser, M.: Syringolin A Selectively Labels the 20 S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines. ChemBioChem 10 (16), pp. 2638 - 2643 (2009)

Meltzer, M.; Hasenbein, S.; Mamant, N.; Merdanovic, M.; Poepsel, S.; Hauske, P.; Kaiser, M.; Huber, R.; Krojer, T.; Clausen, T. et al.; Ehrmann, M.: Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli. Research in Microbiology 160 (9 Sp. Iss.), pp. 660 - 666 (2009)