Publications of M. Than

Keil, C.; Maskos, K.; Than, M.; Hoopes, J.T.; Huber, R.; Tan, F.; Deddish, P.A.; Erdös, E.G.; Skidgel, R.A.; Bode, W.: Crystal Structure of the Human Carboxypeptidase N (Kininase I) Catalytic Domain. Journal of Molecular Biology 366, pp. 504 - 516 (2007)

Steiner, H.; Than, M.; Bode, W.; Haass, C.: Pore-forming scissors? A first structural glimpse of gamma-secretase. Trends in Biochemical Sciences 31 (9), pp. 491 - 493 (2006)

Steinmetzer, T.; Schweinitz, A.; Sturzebecher, A.; Donnecke, D.; Uhland, K.; Schuster, O.; Steinmetzer, P.; Muller, F.; Friedrich, R.; Than, M. E. et al.; Bode, W.; Sturzbecher, J.: Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. Journal of Medicinal Chemistry 49 (14), pp. 4116 - 4126 (2006)

Rohr, K. B.; Selwood, T.; Marquardt, U.; Huber, R.; Schechter, N. M.; Bode, W.; Than, M. E.: X-ray structures of free and leupeptin-complexed human alpha I-tryptase mutants: Indication for an alpha ->beta-tryptase transition. Journal of Molecular Biology 357 (1), pp. 195 - 209 (2006)

Kacprzak, M. M.; Than, M. E.; Juliano, L.; Juliano, M. A.; Bode, W.; Lindberg, I.: Mutations of the PC2 substrate binding pocket alter enzyme specificity. Journal of Biological Chemistry 280 (36), pp. 31850 - 31858 (2005)

Than, M. E.; Bourenkov, G. P.; Henrich, S.; Mann, K.; Bode, W.: The NC1 dimer of human placental basement membrane collagen IV: does a covalent crosslink exist? Biological Chemistry 386 (8), pp. 759 - 766 (2005)

Than, M. E.; Henrich, S.; Bourenkov, G. P.; Bartunik, H. D.; Huber, R.; Bode, W.: The endoproteinase furin contains two essential Ca2+ ions stabilizing its N-terminus and the unique S1 specificity pocket. Acta Crystallographica Section D-Biological Crystallography 61, pp. 505 - 512 (2005)

Henrich, S.; Lindberg, I.; Bode, W.; Than, M. E.: Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity. Journal of Molecular Biology 345 (2), pp. 211 - 227 (2005)

Keil, C.; Huber, R.; Bode, W.; Than, M. E.: Cloning, expression, crystallization and initial crystallographic analysis of the C-terminal domain of the amyloid precursor protein APP. Acta Crystallographica Section D-Biological Crystallography 60, pp. 1614 - 1617 (2004)

Kacprzak, M. M.; Peinado, J. R.; Than, M. E.; Appel, J.; Henrich, S.; Lipkind, G.; Houghten, R. A.; Bode, W.; Lindberg, I.: Inhibition of furin by polyarginine-containing peptides - Nanomolar inhibition by NONA-D-arginine. Journal of Biological Chemistry 279 (35), pp. 36788 - 36794 (2004)

Than, M. E.; Helm, M.; Simpson, D. J.; Lottspeich, F.; Huber, R.; Gietl, C.: The 2.0 angstrom crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm. Journal of Molecular Biology 336 (5), pp. 1103 - 1116 (2004)

Henrich, S.; Cameron, A.; Bourenkov, G. P.; Kiefersauer, R.; Huber, R.; Lindberg, I.; Bode, W.; Than, M. E.: The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nature Structural Biology 10 (7), pp. 520 - 526 (2003)

Than, M. E.; Henrich, S.; Huber, R.; Ries, A.; Mann, K.; Kühn, K.; Timpl, R.; Bourenkov, G. P.; Bartunik, H. D.; Bode, W.: The 1.9-angstrom crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link. Proceedings of the National Academy of Sciences of the United States of America 99 (10), pp. 6607 - 6612 (2002)

Soulimane, T.; Kiefersauer, R.; Than, M. E.: Ba₃-Type cytochrome c oxidase from Thermus thermophilus: Purification, crystallization and crystal transformation. In: Membrane Protein Purification and Crystallization, pp. 229 - 251 (Eds. Hunte, C.; Schägger, H.; von Jagow, G.). Elsevier Science, San Diego (2003)

Than, M. E.: Röntgenstrukturanalyse der ba₃ Cytochrom-c Oxidase aus Thermus thermophilus und ihres Substrates Cytochrom-c₅₅₂. Dissertation, Technische Universität, München (2000)

Than, M. E.: Structure, Function and Inhibition of the Prohormone/Proprotein Convertase Family of Endoproteinases. Habilitation, Ludwig-Maximilians-Universität, München (2006)