Publications of Mekdes Debela

Debela, M.; Magdolen, V.; Skala, W.; Elsasser, B.; Schneider, E. L.; Craik, C. S.; Biniossek, M. L.; Schilling, O.; Bode, W.; Brandstetter, H. et al.; Goettig, P.: Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. Scientific Reports 8, 10705 (2018)

Skala, W.; Utzschneider, D. T.; Magdolen, V.; Debela, M.; Guo, S.; Craik, C. S.; Brandstetter, H.; Goettig, P.: Structure-Function Analyses of Human Kallikrein-related Peptidase 2 Establish the 99-Loop as Master Regulator of Activity. JOURNAL OF BIOLOGICAL CHEMISTRY 289 (49), pp. 34267 - 34283 (2014)

Beaufort, N.; Plaza, K.; Utzschneider, D.; Schwarz, A.; Burkhart, J. M.; Creutzburg, S.; Debela, M.; Schmitt, M.; Ries, C.; Magdolen, V.: Interdependence of kallikrein-related peptidases in proteolytic networks. Biological Chemistry 391 (5), pp. 581 - 587 (2010)

Yoon, H.; Blaber, S. I.; Debela, M.; Goettig, P.; Scarisbrick, I. A.; Blaber, M.: A completed KLK activome profile: investigation of activation profiles of KLK9, 10, and 15. Biological Chemistry (4), pp. 373 - 377 (2009)

Debela, M.; Beaufort, N.; Magdolen, V.; Schechter, N. M.; Craik, C. S.; Schmitt, M.; Bode, W.; Goettig, P.: Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7. Biological Chemistry 389 (6), pp. 623 - 632 (2008)

Debela, M.; Goettig, P.; Magdolen, V.; Huber, R.; Schechter, N. M.; Bode, W.: Structural basis of the zinc inhibition of human tissue kallikrein 5. Journal of Molecular Biology 373 (4), pp. 1017 - 1031 (2007)

Debela, M.; Hess, P.; Magdolen, V.; Schechter, N. M.; Steiner, T.; Huber, R.; Bode, W.; Goettig, P.: Chymotryptic specificity determinants in the 1.0 angstrom structure of the zinc-inhibited human tissue kallikrein 7. Proceedings of the National Academy of Sciences of the United States of America 104 (41), pp. 16086 - 16091 (2007)

Debela, M.; Magdolen, V.; Grimminger, V.; Sommerhoff, C.; Messerschmidt, A.; Huber, R.; Friedrich, R.; Bode, W.; Goettig, P.: Crystal structures of human tissue kallikrein 4: Activity modulation by a specific zinc binding site. Journal of Molecular Biology 362 (5), pp. 1094 - 1107 (2006)

Debela, M.; Magdolen, V.; Schechter, N.; Valachova, M.; Lottspeich, F.; Craik, C. S.; Choe, Y.; Bode, W.; Goettig, P.: Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences. Journal of Biological Chemistry 281 (35), pp. 25678 - 25688 (2006)

Beaufort, N.; Debela, M.; Creutzburg, S.; Kellermann, J.; Bode, W.; Schmitt, M.; Pidard, D.; Magdolen, V.: Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR). Biological Chemistry 387 (2), pp. 217 - 222 (2006)

Debela, M.; Magdolen, V.; Bode, W.; Brandstetter, H.; Goettig, P.: Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10. 6th International Symposium on Kallikreins and Kallikrein-Related Peptidases (ISK), Brisbane, AUSTRALIA, September 28, 2015 - October 01, 2015. Biological Chemistry 397 (12), pp. 1251 - 1264 (2016)

Debela, M. H. M.: Crystal Structures of the Human Tissue Kallikreins 4, 5, 7, 20, Characterization of their Substrate Specificity and Analysis of their Various Zinc Inhibition Mechanisms. Dissertation, Technische Universität, München (2007)