Publications of Laura A. Hehl

Hehl, L. A.; Horn-Ghetko, D.; Prabu, J. R.; Vollrath, R.; Tung Vu, D.; Pérez Berrocal, D. A.; Mulder, M. P. C.; van der Heden van Noort, G. J.; Schulman, B. A.: Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5. Nature Chemical Biology 20, pp. 190 - 200 (2024)

Chrustowicz, J.; Sherpa, D.; Li, J.; Langlois, C. R.; Papadopoulou, E. C.; Tung Vu, D.; Hehl, L. A.; Karayel, Ö.; Beier, V.; Gronau, S. v. et al.; Müller, J.; Prabu, J. R.; Mann, M.; Kleiger, G.; Alpi, A. F.; Schulman, B. A.: Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Molecular Cell 84 (2), pp. 293 - 308 (2024)

Hehl, L. A.; Schulman, B. A.: To be (in a transcriptional complex) or not to be (promoting UBR5 ubiquitylation): That is an answer to how degradation controls gene expression. Molecular Cell 83 (15), pp. 2616 - 2618 (2023)

Berrocal, D. A. P. A.; Vishwanatha, T. M.; Horn-Ghetko, D.; Botsch, J. J.; Hehl, L. A.; Kostrhon, S.; Misra, M.; Dikic, I.; Geurink, P. P.; van Dam, H. et al.; Schulman, B. A.; Mulder, M. P. C.: A Pro-Fluorescent Ubiquitin-Based Probe to Monitor Cysteine-Based E3 Ligase Activity. Angewandte Chemie International Edition 62 (32), e202303319 (2023)

Sherpa, D.; Chrustowicz, J.; Qiao, S.; Langlois, C. R.; Hehl, L. A.; Gottemukkala, K. V.; Hansen, F. M.; Karayel, O.; von Gronau, S.; Prabu, J. R. et al.; Mann, M.; Alpi, A. F.; Schulman, B. A.: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Molecular Cell 81 (11), pp. 2445 - 2459.e13 (2021)

Hehl, L. A.: Determining the ubiquitylation mechanisms of UBR5. Dissertation, Technische Universität München, School of Natural Sciences, München (2024)

Hehl, L. A.: Regulation of a ubiquitin conjugating enzyme under different metabolic conditions in Saccharomyces cerevisiae. Master, Univ. Regensburg (2019)