Publications
*Equal contribution, #Correspondence, Lab members
Barrera-Paez JD, Bacman S, Balla T, Van Booven DJ, Gannamedi DP, Stewart J, Mok B, Liu D, Lombard D, Griswold A, Nedialkova DD, Moraes CT. Correcting a pathogenic mouse mitochondrial DNA mutation by base editing. Science Translational Medicine 2025. 17, eadr0792. Full text
Zhong Z, Bailey M, Kim Y-I, Pesaran-Afsharyan N, Parker B, Arathoon L, Li X, Rundle CA, Behrens A, Nedialkova DD, Slavov G, Hassani-Pak K, Lilley KS, Theodoulou F, Mott R. Revisiting the Central Dogma: the distinct roles of genome, methylation, transcription, and translation on protein expression in Arabidopsis thaliana. bioRxiv 2025.01.08.631880. Full text
Rodschinka G, Forcelloni S, Behrens A, Riemenschneider H, Edbauer D, Wani S, Nedialkova DD#. Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control. bioRxiv 2025.01.07.631643. Full text
Reimão-Pinto MM#, Behrens A*, Forcelloni S*, Fröhlich K, Kaya S, Nedialkova DD#. The dynamics and functional impact of tRNA repertoires during early embryogenesis in zebrafish. EMBO Journal 2024. 43:5747 - 5779. Full text
Gao L*, Behrens A*, Rodschinka G, Forcelloni S, Wani S, Strasser K, Nedialkova DD#. Selective gene expression maintains human tRNA anticodon pools during differentiation. Nature Cell Biology 2024. 26 (100–112) Full text
Zhao S, Cordes J, Caban K, Götz M, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R, Stingele J. RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks. Molecular Cell 2023 83(23): 4290-4303. e9. Full text
Behrens A, Nedialkova DD#. Experimental and computational workflow for the analysis of tRNA pools from eukaryotic cells by mim-tRNAseq. STAR Protocols 2022. 3, 101579. Full text
Behrens A, Rodschinka G, Nedialkova DD#. High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq. Molecular Cell 2021. 81(8):1802-1815.e7 Full text
Blasco-Moreno B*, de Campos-Mata L*, Böttcher R, García Martínez J, Jungfleisch J, Nedialkova DD, Chattopadhyay S, Gas M-E, Oliva B, Pérez-Ortín JE, Leidel SA, Choder M, Diez J. The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins. Nature Communications 2019. 10(1):1298. Full text
Mittal N, Guimaraes J, Gross T, Schmidt A, Vina-Vilaseca A, Nedialkova DD, Aeschimann F, Leidel SA, Spang A. Zavolan M. The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan. Nature Communications 2017 8(1):457. Full text
Jungfleisch J, Nedialkova DD*, Dotu I*, Sloan KE. Bruening L, Raineri E, Bohnsack M, Leidel SA. Diez J. A novel and conserved translational control mechanism involving RNA structures within coding sequences. Genome Research 2017. 27(1):95-106. Full text
Lecanda A, Nilges BS, Sharma P, Nedialkova DD, Schwarz J, Vaquerizas JM, Leidel SA. Dual randomization of oligonucleotides to reduce the bias in ribosome profiling libraries. Methods 2016. 107: 89-97. Full text
Laguesse S*, Creppe C*, Nedialkova DD, Prévot P-P. Borgs L, Huysseune S, Franco B, Duysens G, Krusy N, Lee G, Thelen N, Thiry M, Close P, Chariot A, Malgrange B, Leidel SA. Godin JD, Nguyen L. A dynamic unfolded protein response contributes to the control of cortical neurogenesis. Developmental Cell 2015. 35 (5): 553-67. Full text
Nedialkova DD, Leidel SA. Optimization of codon translation rates via tRNA modifications maintains proteome integrity. Cell 2015 161 (7): 1606-1618. Full text
Nedialkova DD, Gorbalenya AE, Snijder EJ. Arterivirus nsp1 modulates the accumulation of minus-strand templates to control the relative abundance of viral mRNAs. PLoS Pathogens 2010. 6(2): e1000772. Full text
Nedialkova DD, Ulferts R, van den Born E, Lauber C, Gorbalenya AE, Ziebuhr J, Snijder EJ. Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus-wide conservation of a replicative endoribonuclease. Journal of Virology 2009. 83 (11): 5671–5682. Full text
Tijms MA*, Nedialkova DD*, Zevenhoven-Dobbe JC*, Gorbalenya AE, Snijder EJ. Arterivirus subgenomic mRNA synthesis and virion biogenesis depend on the multifunctional nsp1 autoprotease. Journal of Virology 2007. 81 (19): 10496-505. Full text
Posthuma CC, Nedialkova DD. Zevenhoven-Dobbe JC, Blokhuis JH, Gorbalenya AE, Snijder EJ. Site-directed mutagenesis of the nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle. Journal of Virology 2006. 80 (4): 1653-61 [OA]. Full text