Multi-Locus Mapping of Genetic Heterogeneity (FAIS)
Summary
We present an algorithm for discovering contiguous sets of SNPs in a genome that are associated to a phenotype of interest under a model of genetic heterogeneity. The algorithm can search any contiguous set of SNPs in the genome and still properly correct for mutiple testing, while retaining statistical power.
Code
The code is available in our GitHub repository here.
Publication
Genome-wide detection of intervals of genetic heterogeneity associated with complex traits
Felipe Llinares-López, Dominik G. Grimm, Dean A. Bodenham, Udo Gieraths, Mahito Sugiyama, Beth Rowan and Karsten Borgwardt
ISMB 2015 and Bioinformatics 2015, 31 (12): i240-i249
Online | ETH Research Collection | Project page | GitHub
Contact Felipe Llinares López for questions regarding usage or reporting bugs.