Publications of J. Tatzelt

Resenberger, U. K.; Harmeier, A.; Woerner, A. C.; Goodman, J. L.; Müller, V.; Krishnan, R.; Vabulas, R. M.; Kretzschmar, H. A.; Lindquist, S.; Hartl, F. U. et al.; Multhaup, G.; Winklhofer, K. F.; Tatzelt, J.: The cellular prion protein mediates neurotoxic signalling of beta-sheet-rich conformers independent of prion replication. EMBO Journal 30 (10), pp. 2057 - 2070 (2011)

Schumacher, M. C.; Resenberger, U.; Seidel, R. P.; Becker, C. F. W.; Winklhofer, K. F.; Oesterhelt, D.; Tatzelt, J.; Engelhard, M.: Synthesis of a GPI Anchor Module Suitable for Protein Post-Translational Modification. Biopolymers 94 (4 Sp. Iss.), pp. 457 - 464 (2010)

Rambold, A. S.; Miesbauer, M.; Olschewski, D.; Seidel, R.; Riemer, C.; Smale, L.; Brumm, L.; Levy, M.; Gazit, E.; Oesterhelt, D. et al.; Baier, M.; Becker, C. F. W.; Engelhard, M.; Winklhofer, K. F.; Tatzelt, J.: Green tea extracts interfere with the stress-protective activity of PrPC and the formation of PrPSc. Journal of Neurochemistry 107 (1), pp. 218 - 229 (2008)

Olschewski, D.; Seidel, R.; Miesbauer, M.; Rambold, A. S.; Oesterhelt, D.; Winklhofer, K. F.; Tatzelt, J.; Engelhard, M.; Becker, C. F. W.: Semisynthetic murine prion protein equipped with a GPI anchor mimic incorporates into cellular membranes. Chemistry & Biology 14 (9), pp. 994 - 1006 (2007)

Miesbauer, M.; Bamme, T.; Riemer, C.; Oidtmann, B.; Winklhofer, K. F.; Baier, M.; Tatzelt, J.: Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor. Biochemical and Biophysical Research Communications 341 (1), pp. 218 - 224 (2006)

Dumpitak, C.; Beekes, M.; Weinmann, N.; Metzger, S.; Winklhofer, K. F.; Tatzelt, J.; Riesner, D.: The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of alpha-linked polyglucose. Biological Chemistry 386 (11), pp. 1149 - 1155 (2005)

Bertsch, U.; Winklhofer, K. F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F. U.; Tavan, P.; Tatzelt, J.; Kretzschmar, H. A.; Giese, A.: Single molecule analysis of protein aggregation and prions by SIFT. FEBS Journal 272 (Suppl. Suppl. 1), pp. 338 - 339 (2005)

Bertsch, U.; Winklhofer, K. F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F. U.; Tavan, P.; Tatzelt, J.; Kretzschmar, H. A.; Giese, A.: Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets. Journal of Virology 79 (12), pp. 7785 - 7791 (2005)

Kretzschmar, H. A.; Bertsch, U.; Winklhofer, K. F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F. U.; Tavan, P.; Tatzelt, J.; Giese, A.: Single molecule analysis of protein aggregation and prions by sift. Journal of Neuropathology and Experimental Neurology 64 (5), p. 441 - 441 (2005)

Kiachopoulos, S.; Bracher, A.; Winklhofer, K. F.; Tatzelt, J.: Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor. Journal of Biological Chemistry 280 (10), pp. 9320 - 9329 (2005)

Uelhoff, A.; Tatzelt, J.; Aguzzi, A.; Winklhofer, K. F.; Haass, C.: A pathogenic PrP mutation and Doppel interfere with polarized sorting of the prion protein. Journal of Biological Chemistry 280 (7), pp. 5137 - 5140 (2005)

Henn, I. H.; Gostner, J. M.; Lackner, P.; Tatzelt, J.; Winklhofer, K. F.: Pathogenic mutations inactivate parkin by distinct mechanisms. Journal of Neurochemistry 92 (1), pp. 114 - 122 (2005)

Leffers, K. W.; Schell, J.; Jansen, K.; Lucassen, R.; Kaimann, T.; Nagel-Steger, L.; Tatzelt, J.; Riesner, D.: The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites. Journal of Molecular Biology 344 (3), pp. 839 - 853 (2004)

Tatzelt, J.; Winklhofer, K. F.: Folding and misfolding of the prion protein in the secretory pathway. Amyloid-Journal of Protein Folding Disorders 11 (3), pp. 162 - 172 (2004)

Kiachopoulos, S.; Heske, J.; Tatzelt, J.; Winklhofer, K. F.: Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation. Traffic 5 (6), pp. 426 - 436 (2004)

Heske, J.; Heller, U.; Winklhofer, K. F.; Tatzelt, J.: The C-terminal globular domain of the prion protein is necessary and sufficient for import into the endoplasmic reticulum. Journal of Biological Chemistry 279 (7), pp. 5435 - 5443 (2004)

Winklhofer, K. F.; Henn, I. H.; Kay-Jackson, P. C.; Heller, U.; Tatzelt, J.: Inactivation of parkin by oxidative stress and C-terminal truncations - A protective role of molecular chaperones. Journal of Biological Chemistry 278 (47), pp. 47199 - 47208 (2003)

Heller, U.; Winklhofer, K. F.; Heske, J.; Reintjes, A.; Tatzelt, J.: Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability - A critical role for the putative transmembrane domain. Journal of Biological Chemistry 278 (38), pp. 36139 - 36147 (2003)

Winklhofer, K. F.; Heller, U.; Reintjes, A.; Tatzelt, J.: Inhibition of complex glycosylation increases the formation of PrPsc. Traffic 4 (5), pp. 313 - 322 (2003)

Winklhofer, K. F.; Heske, J.; Heller, U.; Reintjes, A.; Muranyi, W.; Moarefi, I.; Tatzelt, J.: Determinants of the in vivo folding of the prion protein - A bipartite function of helix 1 in folding and aggregation. Journal of Biological Chemistry 278 (17), pp. 14961 - 14970 (2003)