Brenda Schulman

Brenda Schulman

Research Department Molecular Machines and Signaling (MoMaS)

Structural Biology, Ubiquitin Proteasome System, Ubiquitin-like Protein

An important form of regulation is the modification of proteins and membranes by linking them to the small protein ubiquitin or structurally related ubiquitin-like proteins (UBLs). Ubiquitin and UBLs control timing, subcellular location, composition, conformation and activity of thousands of different proteins and macromolecules. In addition, defects in ubiquitin and UBL pathways are associated with numerous diseases such as cancer, neurodegenerative disorders and viral infections. Brenda Schulman's Department “Molecular Machines and Signaling” has shown that hundreds of microscopic, dynamic, multiprotein molecular machines are transiently transformed into different conformations by specialized regulatory factors to control ubiquitin and UBLs in order to regulate virtually all aspects of cell biology.

 

Research Overview
A widespread mechanism regulating the functions of eukaryotic proteins involves post-translational modification by the small protein ubiquitin (UB) or structurally related ubiquitin-like proteins (UBLs). more

 

Department News

Best Poster Prize: Samuel Maiwald

Best Poster Prize: Samuel Maiwald

July 03, 2025
At the 3rd Joint IMPRS Seminar of IMPRS-ML and IMPRS-BI programs, Sam's poster was selected as the best poster by his peers. Congratulations Sam!
Leo presented at the Dana-Farber Targeted Protein Degradation Webinar Series
Leo showcased his recently published research to an international audience. The recording of his talk is now available online! more
Zebin is awarded the EMBO Postdoctoral Fellowship

Zebin is awarded the EMBO Postdoctoral Fellowship

June 06, 2025
EMBO Postdoctoral Fellowships support excellent postdoctoral researchers throughout Europe and the world for a period of up to two years. Congratulations Zebin!
MoMaS at the GRK2243 Ubiquitylation Symposium
Great representation from our team at the "Understanding Ubiquitylation: From Molecular Mechanisms to Disease" symposium in Würzburg! Brenda was an invited speaker, Leo gave a selected short talk, and Jakob, Sam, and Sara presented posters. Hannah also attended this valuable scientific exchange. more

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